Abstract
The objective of the present study was to evaluate the effect of umbelliferon-α-D-glucopyranosyl-(2I → 1II)-α-D-glucopyranoside (UFD) from Aegle marmelos Corr. on serum glucose, lipid profile and free radical scavenging activity in normal and STZ (streptozotocin) induced diabetic rats. Diabetes was induced by single interperitoneal injecting of streptozotocin (60 mg/kg, i.p.) in the rats. All the rats were divided into following groups; I - nondiabeteic, II - nondiabetic + UFD (40 mg/kg, p.o.), III - diabetic control, IV - UFD (10 mg/kg, p.o.), V - UFD (20 mg/kg, p.o.), VI - UFD (40 mg/kg) and VII - glibenclamide (10 mg/kg, p.o.). Serum glucose level and body weight were determined periodically. Biochemical parameter, antioxidant enzyme and histopathology study were performed on the day 28. Oral glucose tolerance test study was performed to identify the glucose utilization capacity. All the doses of UFD and glibenclamide decrease the level of serum glucose, glycated hemoglobin, glucose-6-phosphatase, fructose-1-6-biphosphate and increased the level of plasma insulin, hexokinase. The UFD doses also showed effects on antioxidant enzymes viz. superoxide dismutase, catalase and glutathione peroxidase which were significantly increa...Continue Reading
References
Aug 19, 1976·The New England Journal of Medicine·R J KoenigA Cerami
May 1, 1988·Diabetes·S Bonner-Weir
Jun 1, 1972·Analytical Biochemistry·A K Sinha
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Feb 1, 1973·Metabolism: Clinical and Experimental·E P Paulsen
Sep 1, 1969·Diabetes·G Brosky, J Logothetopoulos
Mar 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R L LipnickJ A Springer
Nov 30, 1994·Biochemical and Biophysical Research Communications·Z LiuJ Y Chou
Jun 1, 1996·General Pharmacology·J R Hoult, M Payá
Jan 24, 1998·Metabolism: Clinical and Experimental·A L Kennedy, T J Lyons
Nov 6, 2001·Molecular and Cellular Biochemistry·J RajuN Z Baquer
Jan 25, 2003·Clinical and Experimental Pharmacology & Physiology·Muniappan Latha, Leelavinothan Pari
Nov 25, 2003·The Diabetes Educator·UNKNOWN American Association of Diabetes Educators
Mar 24, 2004·Journal of Ethnopharmacology·Annie ShirwaikarRamgopal Bodla
Apr 6, 2004·Experimental Diabesity Research·R AnanthanV Narmatha Bai
Sep 17, 2004·Life Sciences·Kasiappan RaviSorimuthu Subramanian
Dec 24, 2004·Diabetes·Antonio Ceriello
Jan 12, 2005·Life Sciences·Ekrem SezikShigeru Ito
Feb 15, 2005·Journal of Ethnopharmacology·Annie ShirwaikarI S R Punitha
Jul 28, 2005·Atherosclerosis. Supplements·James Shepherd
Oct 21, 2005·Life Sciences·Hasan Fayadh Al-Azzawie, Mohamed-Saiel Saeed Alhamdani
Apr 29, 2006·Journal of Ethnopharmacology·Annie ShirwaikarRakesh Barik
Dec 26, 2006·Chemico-biological Interactions·Palanisamy Arulselvan, Sorimuthu Pillai Subramanian
Aug 12, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·P DaisyE Murugan
Mar 17, 2009·Ecotoxicology and Environmental Safety·Aylin Sepici-DinçelFigen Erkoç
Oct 27, 2009·Journal of Ethnopharmacology·Md Salahuddin, Sunil S Jalalpure
Nov 15, 2011·Asian Pacific Journal of Tropical Medicine·Dinesh KumarJyoti Gupta
Dec 27, 2011·Phytochemistry·Suda ChakthongAkkharawit Kanjana-Opas
Jul 31, 2012·Journal of Ethnopharmacology·Santiagu Stephen IrudayarajSavarimuthu Ignacimuthu
Jul 1, 1998·Indian Journal of Clinical Biochemistry : IJCB·N Z BaquerJ Raju
Jan 12, 2013·BMC Complementary and Alternative Medicine·Danish AhmedVikas Kumar
Feb 19, 2013·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Mohammad AslamKalim Javed
Sep 10, 2013·BMC Complementary and Alternative Medicine·Vikas KumarMohd Mujeeb
Oct 22, 2013·BMC Complementary and Alternative Medicine·Vikas KumarMohd Mujeeb
Citations
Feb 26, 2014·BMC Complementary and Alternative Medicine·Vikas KumarMohd Mujeeb
Jun 2, 2015·Journal of Food Science and Technology·Vikas KumarMohd Mujeeb
Sep 8, 2015·Journal of Food Science and Technology·Danish AhmedAmita Verma
Jul 15, 2015·SpringerPlus·Danish AhmedManju Sharma
Apr 22, 2015·Food & Function·Vikas KumarFiroz Anwar
Jun 14, 2016·Journal of Diabetes Research·Du-Bois AsanteJoseph Budu Dadzie
Sep 16, 2016·Inflammopharmacology·Amita VermaVikas Kumar
Apr 11, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Miao YuYong Sun
Mar 12, 2017·Journal of Complementary & Integrative Medicine·Sonchita R MudiLiaquat Ali
Jul 5, 2017·The Journal of Pharmacy and Pharmacology·Hanbing LiLinghuan Li
Dec 9, 2016·BMC Complementary and Alternative Medicine·Vikas KumarAmita Verma
Nov 1, 2020·Environmental Science and Pollution Research International·Emad H M HassaneinOmnia A M Abd El-Ghafar
May 7, 2021·Journal of Oleo Science·Li HeZhi-Qiang Kang
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·José M Cela-LópezVicente Martínez