Enhanced glycemic control, pancreas protective, antioxidant and hepatoprotective effects by umbelliferon-α-D-glucopyranosyl-(2(I) → 1(II))-α-D-glucopyranoside in streptozotocin induced diabetic rats

SpringerPlus
Vikas KumarMohd Mujeeb

Abstract

The objective of the present study was to evaluate the effect of umbelliferon-α-D-glucopyranosyl-(2I → 1II)-α-D-glucopyranoside (UFD) from Aegle marmelos Corr. on serum glucose, lipid profile and free radical scavenging activity in normal and STZ (streptozotocin) induced diabetic rats. Diabetes was induced by single interperitoneal injecting of streptozotocin (60 mg/kg, i.p.) in the rats. All the rats were divided into following groups; I - nondiabeteic, II - nondiabetic + UFD (40 mg/kg, p.o.), III - diabetic control, IV - UFD (10 mg/kg, p.o.), V - UFD (20 mg/kg, p.o.), VI - UFD (40 mg/kg) and VII - glibenclamide (10 mg/kg, p.o.). Serum glucose level and body weight were determined periodically. Biochemical parameter, antioxidant enzyme and histopathology study were performed on the day 28. Oral glucose tolerance test study was performed to identify the glucose utilization capacity. All the doses of UFD and glibenclamide decrease the level of serum glucose, glycated hemoglobin, glucose-6-phosphatase, fructose-1-6-biphosphate and increased the level of plasma insulin, hexokinase. The UFD doses also showed effects on antioxidant enzymes viz. superoxide dismutase, catalase and glutathione peroxidase which were significantly increa...Continue Reading

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Citations

Feb 26, 2014·BMC Complementary and Alternative Medicine·Vikas KumarMohd Mujeeb
Jun 14, 2016·Journal of Diabetes Research·Du-Bois AsanteJoseph Budu Dadzie
Jul 5, 2017·The Journal of Pharmacy and Pharmacology·Hanbing LiLinghuan Li
Nov 1, 2020·Environmental Science and Pollution Research International·Emad H M HassaneinOmnia A M Abd El-Ghafar
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·José M Cela-LópezVicente Martínez

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Methods Mentioned

BETA
column chromatography
MDA
NMR
glycosylation

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