Enhanced hematopoietic stem cell function mediates immune regeneration following sex steroid blockade

Stem Cell Reports
Danika M KhongAnn P Chidgey

Abstract

Mechanisms underlying age-related defects within lymphoid-lineages remain poorly understood. We previously reported that sex steroid ablation (SSA) induced lymphoid rejuvenation and enhanced recovery from hematopoietic stem cell (HSC) transplantation (HSCT). We herein show that, mechanistically, SSA induces hematopoietic and lymphoid recovery by functionally enhancing both HSC self-renewal and propensity for lymphoid differentiation through intrinsic molecular changes. Our transcriptome analysis revealed further hematopoietic support through rejuvenation of the bone marrow (BM) microenvironment, with upregulation of key hematopoietic factors and master regulatory factors associated with aging such as Foxo1. These studies provide important cellular and molecular insights into understanding how SSA-induced regeneration of the hematopoietic compartment can underpin recovery of the immune system following damaging cytoablative treatments. These findings support a short-term strategy for clinical use of SSA to enhance the production of lymphoid cells and HSC engraftment, leading to improved outcomes in adult patients undergoing HSCT and immune depletion in general.

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Citations

Apr 19, 2016·Immunological Reviews·Mohammed S ChaudhryMarcel R M van den Brink
Dec 21, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohammed S ChaudhryMarcel R M van den Brink
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Sep 10, 2020·Frontiers in Immunology·Sinéad Kinsella, Jarrod A Dudakov
Sep 26, 2020·Frontiers in Immunology·Jastaranpreet SinghJuan Carlos Zúñiga-Pflücker
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Feb 21, 2021·Seminars in Immunopathology·David GranadierJarrod A Dudakov
Nov 16, 2017·Experimental Cell Research·Danika KhongBiju Parekkadan
Jul 13, 2021·Frontiers in Immunology·Linda QuatriniLorenzo Moretta

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

calc
Ingenuity Pathway Analysis ( IPA )
Partek

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