PMID: 2493108Feb 1, 1989Paper

Enhanced high energy phosphate recovery with ribose infusion after global myocardial ischemia in a canine model

The Journal of Surgical Research
John A St CyrJ E Foker

Abstract

High energy phosphate levels are depressed following global ischemia and require several days to completely recover. Short-term methods to enhance ATP recovery have included infusion of ATP precursors, inhibition of enzymes that catabolize AMP, and membrane transport stabilization. Several precursors have been used to augment adenine nucleotide synthesis including adenosine, inosine, adenine, and ribose. Because of the short-term nature of previous experiments, recovery had been incomplete and the effects in the intact animal unknown. The purpose of this study was to determine the effects of ribose infusion in a long-term model of global ischemia and attempt to identify the precursor which limits myocardial ATP regeneration in the intact animal. Global myocardial ischemia (20 min, 37 degrees C) was produced in dogs on cardiopulmonary bypass. With reperfusion either ribose (80 mM) in normal saline or normal saline alone was infused at 1 ml/min into the right atrium and the animals were followed for 24 hr. Ventricular biopsies were obtained through an indwelling ventricular cannula prior to ischemia, at the end of ischemia, and 4 and 24 hr postischemia and analyzed for adenine nucleotides and creatine phosphate levels. Radiolabel...Continue Reading

References

Mar 1, 1970·Journal of Molecular and Cellular Cardiology·W KüblerH J Bretschneider
Aug 1, 1982·Journal of Molecular and Cellular Cardiology·H G Zimmer
Apr 1, 1983·The Journal of Surgical Research·H B WardJ E Foker

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Citations

Dec 1, 1991·Journal of the American College of Cardiology·M G HegewaldR A Wilson
Feb 14, 2002·Biochemical Pharmacology·Catia Barsotti, Piero Luigi Ipata
Feb 28, 2003·Medical Hypotheses·D F PaulyJ A St Cyr
Dec 6, 2008·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Linda ShecterleJohn St Cyr
Jul 25, 2009·Journal of Medicinal Food·John G SeifertJohn A St Cyr
Feb 10, 2009·Cardiovascular Ultrasound·Stephen G SawadaHarvey Feigenbaum
Dec 17, 2008·Nutrition Research·Melanie L FreemanSusan S Percival
Nov 13, 2004·Pharmacotherapy·Benjamin Gebhart, James A Jorgenson
Oct 15, 2013·Plant Biology·J Ampofo-AsiamaB M Nicolai
Dec 1, 1989·The Journal of Surgical Research·J R MahoneyJ E Foker
Jun 16, 2009·Progress in Cardiovascular Nursing·Susan WagnerJohn A St Cyr
Feb 12, 2011·Therapeutic Advances in Cardiovascular Disease·Linda M ShecterleJohn A St Cyr
Jun 23, 2011·Therapeutic Advances in Cardiovascular Disease·David J PerkowskiJ A St Cyr
Feb 24, 2015·Therapeutic Advances in Cardiovascular Disease·Melike BayramWilliam T Abraham
Jan 11, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·D F Pauly, C J Pepine
Jul 15, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Mahesh ThirunavukkarasuNilanjana Maulik
Mar 17, 2020·Nutrition Research Reviews·Arrigo F G CiceroUNKNOWN International Lipid Expert Panel
Jul 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Regis R LambertsGer J M Stienen
Oct 18, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Andrey V GourineJianyi Zhang
Feb 17, 1998·Basic Research in Cardiology·T P Geisbuhler

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