Enhanced HIV-specific immune responses in chronically HIV-infected patients receiving didanosine plus hydroxyurea

AIDS
Mariola LópezVincent Soriano

Abstract

The role of hydroxyurea (HU) in the treatment of HIV infection remains controversial. HU potentiates didanosine (ddI) antiviral activity and might exert immunomodulatory effects. Immunologic parameters were examined in HIV-infected patients enrolled in a simplification trial in which ddI-HU was provided to subjects who had been on complete virus suppression under highly active antiretroviral therapy (HAART) for longer than 6 months. A total of 84 of these patients showed plasma viraemia repeatedly below 5000 HIV-RNA copies/ml, and were the main study population. A group of 22 patients who continued on HAART and another of 22 drug-naive HIV-positive individuals were taken as controls. At 12 months, the levels of naive and memory T-cell subsets were similar in patients on ddI-HU and under HAART, whereas immune activation tended to be lower in the former group. The frequency of HIV-specific CD8+ T cells (CTL) directed against 125 peptides derived from Gag, Pol, Env, Nef and HIV regulatory proteins was similar among patients on ddI-HU and untreated controls, and significantly higher than in patients under HAART. This higher CTL response in patients on ddI-HU was seen even when considering only subjects with undetectable viral load....Continue Reading

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Citations

Jun 10, 2005·AIDS Research and Human Retroviruses·Franco LoriJ Lisziewicz
Aug 17, 2006·AIDS Research and Human Retroviruses·José Miguel BenitoVincent Soriano
Jan 15, 2008·Current Opinion in Infectious Diseases·Sarah FidlerJonathan Weber
Feb 17, 2011·Immunotherapy·June Myung Kim, Sang Hoon Han
May 22, 2007·Clinical and Experimental Immunology·J M BenitoV Soriano
May 31, 2016·American Journal of Hematology·Emmanuel BalandyaJulie Makani

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