Enhanced humoral response to influenza vaccine in aged mice with a novel adjuvant, rOv-ASP-1

Vaccine
Jiu JiangDonna M Murasko

Abstract

Immunization is the best way to prevent seasonal epidemics and pandemics of influenza. There are two kinds of influenza vaccines available in the United States: an inactivated vaccine (TIV) and an attenuated vaccine; however, only TIV is approved for immunization of the elderly population. While the aged population has the highest rate of influenza vaccination, the protective efficacy is low as evidenced by elderly individuals having the highest mortality associated with influenza. Recently, we reported that an adjuvant derived from the helminth parasite Onchocerca volvulus, named O. volvulus activation-associated secreted protein-1 (Ov-ASP-1), can significantly enhance the protective efficacy of an inactivated vaccine (TIV) in young adult mice. In the current study, we examined whether this recombinant Ov-ASP-1 (rOv-ASP-1) can enhance the efficacy of TIV in aged mice as well. While primary immunization with TIV alone produced only a low level of influenza-specific antibodies (total IgG, IgG1, and IgG2c) in aged mice, the antibody levels were significantly increased after immunization with TIV+rOv-ASP-1. More importantly, the level of the total IgG in aged mice administered TIV+rOv-ASP-1 was comparable to that of young adult mi...Continue Reading

References

Dec 7, 1994·JAMA : the Journal of the American Medical Association·T M GovaertJ A Knottnerus
Feb 1, 1997·Vaccine·J C Cox, A R Coulter
Jul 22, 1998·Journal of Immunological Methods·R M MartinA M Lew
Aug 26, 2000·Molecular and Biochemical Parasitology·W TaweS Lustigman
Jun 5, 2002·Mechanisms of Ageing and Development·John Leander Z PoDonna M Murasko
Jan 9, 2003·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Apr 4, 2003·The New England Journal of Medicine·Kristin L NicholMarika Iwane
Nov 25, 2005·Current Drug Delivery·Manish DiwanJohn Samuel
Oct 5, 2007·The New England Journal of Medicine·Kristin L NicholEelko Hak
Nov 23, 2007·Immunity·Amy S McKeePhilippa Marrack
Feb 24, 2010·Journal of Internal Medicine·G D DeansJ E McElhaney
Jul 2, 2010·Journal of Virology·Natalia A IlyushinaRichard J Webby
Aug 28, 2010·Science·Robert W Doms
Oct 28, 2010·Current Opinion in HIV and AIDS·Darrick Carter, Steven G Reed
Mar 7, 2012·Clinical Interventions in Aging·Pierre-Olivier LangRichard Aspinall
May 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Gui-Mei LiRafi Ahmed
Nov 13, 2013·Immunology and Cell Biology·Michelle A Linterman

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Methods Mentioned

BETA
ELISA

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