Enhanced hypoglycemic activity following intratracheal administration of insulin microcrystal suspension with injection adjuvant

Bioscience, Biotechnology, and Biochemistry
Hyun-Kyung LeeChan-Wha Kim

Abstract

The pulmonary route appears to be the most attractive alternative for non-invasive systemic delivery of insulin. We have shown the feasibility of insulin microcrystals as a long-acting formulation for pulmonary delivery. In this study, we examined the effects of adjuvant for pulmonary formulations of insulin, such as protamine, zinc, and glycerol. In an in vivo experiment with rats, only zinc enhanced the hypoglycemic effect of insulin microcrystals, with 17% of minimum reductions in blood glucose (%MRBG) and a 44% decrement in the blood glucose level (D%9h).

References

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Apr 2, 2004·Bioscience, Biotechnology, and Biochemistry·Sung Hee ChoiChan-Wha Kim
May 26, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jai-Hyun KwonChan-Wha Kim

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Citations

Dec 8, 2009·Bioscience, Biotechnology, and Biochemistry·Se-Hwan LimChan-Wha Kim
Sep 21, 2007·Advanced Drug Delivery Reviews·El-Sayed KhafagyKozo Takayama
Apr 25, 2007·International Journal of Pharmaceutics·Sang-Ha ParkChan-Wha Kim

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