Dec 1, 1978

Enhanced hypothalamic noradrenaline biosynthesis in Goldblatt I renovascular hypertension

Clinical Science and Molecular Medicine. Supplement
V DequattroH Whigham

Abstract

1. Hypertension was induced in rats by renal artery clip with the contralateral kidney removed (Goldblatt I) or left intact (Goldblatt II). 2. Plasma noradrenaline was increased 62% in the Goldblatt I animals after 3 weeks. 3. Hypothalamic tyrosine hydroxylase and dopamine beta-hydroxylase activities, and the concentration of noradrenaline were increased in the Goldblatt I animals after 3 weeks. 4. Enhanced hypothalamic noradrenaline synthesis may be a pathogenic factor in Goldblatt I renovascular hypertension.

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Mentioned in this Paper

Hypertension, Renovascular
Sympathetic Nervous System
Organum Vasculosum Laminae Terminalis
Nephrectomy
Norepinephrine, (+, -)-Isomer
Dopamine-beta-monooxygenase
Dystonia, DOPA-RESPONSIVE, With OR Without Hyperphenylalaninemia, Autosomal Recessive (Disorder)
Dopamine Beta Hydroxylase Deficiency
Renal Hypertension
Tyrosine 3-Monooxygenase

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