Enhanced immune responses by skin vaccination with influenza subunit vaccine in young hosts

Vaccine
Dimitrios G KoutsonanosRichard W Compans

Abstract

Skin has gained substantial attention as a vaccine target organ due to its immunological properties, which include a high density of professional antigen presenting cells (APCs). Previous studies have demonstrated the effectiveness of this vaccination route not only in animal models but also in adults. Young children represent a population group that is at high risk from influenza infection. As a result, this group could benefit significantly from influenza vaccine delivery approaches through the skin and the improved immune response it can induce. In this study, we compared the immune responses in young BALB/c mice upon skin delivery of influenza vaccine with vaccination by the conventional intramuscular route. Young mice that received 5 μg of H1N1 A/Ca/07/09 influenza subunit vaccine using MN demonstrated an improved serum antibody response (IgG1 and IgG2a) when compared to the young IM group, accompanied by higher numbers of influenza-specific antibody secreting cells (ASCs) in the bone marrow. In addition, we observed increased activation of follicular helper T cells and formation of germinal centers in the regional lymph nodes in the MN immunized group, rapid clearance of the virus from their lungs as well as complete surv...Continue Reading

References

Mar 10, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L B BrydakM Sieniawska
Mar 22, 2002·Nature Reviews. Immunology·J A BerzofskyI M Belyakov
Jan 9, 2003·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Sep 16, 2004·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Feb 5, 2005·American Journal of Epidemiology·Ira M Longini, M Elizabeth Halloran
Dec 16, 2005·The New England Journal of Medicine·Niranjan BhatUNKNOWN Influenza Special Investigations Team
Feb 6, 2007·Seminars in Immunology·Heung Kyu Lee, Akiko Iwasaki
Apr 1, 2008·The American Journal of Medicine·Michael B RothbergRichard B Brown
Mar 11, 2009·PloS One·Dimitrios G KoutsonanosIoanna Skountzou
Mar 24, 2009·Immunity·Nicolas FazilleauMichael G McHeyzer-Williams
Apr 8, 2009·Expert Review of Vaccines·Arnold S Monto, Suzanne E Ohmit
Nov 3, 2009·The Lancet Infectious Diseases·Terho Heikkinen, Ville Peltola
Dec 1, 2009·European Journal of Immunology·Kristina Rothaeusler, Nicole Baumgarth
Dec 23, 2009·JAMA : the Journal of the American Medical Association·Terry NolanMichael Greenberg
Jul 20, 2010·Nature Medicine·Sean P SullivanMark R Prausnitz
Aug 18, 2010·Vaccine·Arnold S Monto
Nov 9, 2010·Ageing Research Reviews·Janet E McElhaney
Nov 19, 2010·The New England Journal of Medicine·Linda C Lambert, Anthony S Fauci
Jun 10, 2011·American Journal of Obstetrics and Gynecology·Helen DingJames A Singleton
Jun 21, 2011·The Journal of Infectious Diseases·Dimitrios G KoutsonanosIoanna Skountzou
Feb 2, 2012·Human Vaccines & Immunotherapeutics·Giancarlo IcardiFilippo Ansaldi
Mar 8, 2012·MBio·Maria del Pilar MartinRichard W Compans
Sep 26, 2012·Expert Review of Vaccines·Ali Rowhani-RahbarRoger Baxter
Dec 26, 2012·Advanced Drug Delivery Reviews·Steffi HansenUlrich F Schaefer
Feb 13, 2013·Journal of Korean Medical Science·Eun Kyeong KangDong Ho Kim
Mar 13, 2014·European Journal of Immunology·Toshitada TakemoriKlaus Rajewsky
May 20, 2014·Immunologic Research·Alexander W BoydenThomas J Waldschmidt

❮ Previous
Next ❯

Citations

Nov 13, 2015·Expert Opinion on Drug Delivery·N Sanoj RejinoldYeu-Chun Kim
Sep 1, 2015·Vaccine·Marcel B M Teunissen, Darin Zehrung
Nov 26, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jaya Arya, Mark R Prausnitz
May 15, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Teena MohanBao-Zhong Wang
Jun 22, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·E Stein EsserIoanna Skountzou
Oct 19, 2016·Human Vaccines & Immunotherapeutics·Sarah MarshallAnne C Moore
May 23, 2017·Therapeutic Delivery·Chong In ShinYeu-Chun Kim
Apr 28, 2018·The Journal of Infectious Diseases·Jessica C JoycePaul A Rota
Feb 23, 2020·Journal of Clinical Medicine·Rezvan JamaledinPaolo Antonio Netti
Jul 16, 2020·Human Vaccines & Immunotherapeutics·Thuy Trang NguyenJung-Hwan Park
Jan 27, 2019·Nature Reviews. Immunology·Ashley L St John, Abhay P S Rathore
Jun 21, 2018·Viruses·Julia Niessl, Daniel E Kaufmann
Jun 28, 2018·Drug Delivery and Translational Research·Song LiMark Prausnitz
Aug 24, 2018·Open Biology·Abhay P S Rathore, Ashley L St John
Feb 19, 2021·Drug Delivery and Translational Research·Carmine D'AmicoHélder A Santos
May 10, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jessica C JoyceMark R Prausnitz
Jun 3, 2021·International Journal of Molecular Sciences·Philip W Wertz
Nov 23, 2021·Pharmaceutical Development and Technology·Thuy Trang NguyenGiau Van Vo

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
FACS

Software Mentioned

FlowJo

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.