Enhanced in vitro and in vivo cellular imaging with green tea coated water-soluble iron oxide nanocrystals.

ACS Applied Materials & Interfaces
Lisong XiaoSanjay Mathur

Abstract

Fully green and facile redox chemistry involving reduction of colloidal iron hydroxide (Fe(OH)3) through green tea (GT) polyphenols produced water-soluble Fe3O4 nanocrystals coated with GT extracts namely epigallocatechin gallate (EGCG) and epicatechin (EC). Electron donating polyphenols stoichiometrically reduced Fe(3+) ions into Fe(2+) ions resulting in the formation of magnetite (Fe3O4) nanoparticles and corresponding oxidized products (semiquinones and quinones) that simultaneously served as efficient surface chelators for the Fe3O4 nanoparticles making them dispersible and stable in water, PBS, and cell culture medium for extended time periods. As-formed iron oxide nanoparticles (2.5-6 nm) displayed high crystallinity and saturation magnetization as well as high relaxivity ratios manifested in strong contrast enhancement observed in T2-weighted images. Potential of green tea-coated superparamagnetic iron oxide nanocrystals (SPIONs) as superior negative contrast agents was confirmed by in vitro and in vivo experiments. Primary human macrophages (J774A.1) and colon cancer cells (CT26) were chosen to assess cytotoxicity and cellular uptake of GT-, EGCGq-, and ECq-coated Fe3O4 nanoparticles, which showed high uptake efficienci...Continue Reading

References

Feb 10, 2000·Archives of Biochemistry and Biophysics·W BorsK Stettmaier
Jul 11, 2002·Journal of the American Chemical Society·Shouheng Sun, Hao Zeng
Nov 30, 2004·Nature Materials·Jongnam ParkTaeghwan Hyeon
Sep 1, 2005·Journal of the American Chemical Society·Yong-Min HuhJinwoo Cheon
Feb 6, 2007·Angewandte Chemie·An-Hui LuFerdi Schüth
Aug 2, 2008·The Journal of Physical Chemistry. B·Xianyong LuMingyuan Gao
Feb 14, 2009·Chemical Communications : Chem Comm·Xiao JiaShumei Zhai
Jul 28, 2010·Chemical Communications : Chem Comm·Pablo GuardiaLuis M Liz-Marzán
Jan 13, 2011·Angewandte Chemie·Stéphane QuideauLaurent Pouységu
May 10, 2011·Accounts of Chemical Research·Jin XieXiaoyuan Chen
Aug 11, 2011·Chemical Communications : Chem Comm·Nadia E A El-GamelSanjay Mathur
Jan 31, 2012·Chemical Society Reviews·Tennyson L Doane, Clemens Burda
Dec 10, 2009·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Fengqin HuThomas J Meade
Sep 4, 2014·ACS Applied Materials & Interfaces·Laura WortmannSanjay Mathur

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Citations

May 9, 2016·Journal of Colloid and Interface Science·Rajni VermaAvanish K Srivastava
May 24, 2016·Nutrients·Andreia GranjaSalette Reis
Sep 7, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Kui HeChangqun Cai
Oct 19, 2016·Scientific Reports·Tamilmani VairapperumalNair Balachandran Unni
Jul 20, 2017·ACS Applied Materials & Interfaces·Md Arifur RahimFrank Caruso
Apr 2, 2019·Current Pharmaceutical Design·Alexa CroitoruEcaterina Andronescu
Oct 31, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Umeorah ErnestGhulam Murtaza
Feb 6, 2017·Drug Delivery·Orazio VittorioGiuseppe Cirillo
Aug 28, 2019·Seminars in Cancer Biology·Paola AielloIlaria Peluso
Dec 29, 2020·Drug Delivery·Jiali LiZhiping Zhang
Mar 12, 2021·The Journal of Nutritional Biochemistry·Cijo George VazhappillyH P Vasantha Rupasinghe
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Yong WangShaohui Zheng
Jan 23, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Markus B SchützSanjay Mathur

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