Enhanced in vitro bone marrow cell migration and T-lymphocyte responses in aged mice given subcutaneous thymic epithelial cell grafts

Mechanisms of Ageing and Development
J L HaarN Kenyon


Thymic epithelial cell cultures from newborn CBA/J mice were developed and grown on collagen-coated dextran beads. These thymic epithelial cells were transplanted subcutaneously into aged syngeneic mice. After several weeks, enhanced in vitro migration of host bone marrow cells occurred to supernatants prepared from neonatal thymus cultures in thymic epithelial cell grafted mice compared to control aged mice. Percent migration equaled that of migration from control young adult mice. In addition, enhanced T-lymphocyte responses were observed in aged mice given thymic epithelial cell grafts as compared to aged controls.


Feb 1, 1992·Mechanisms of Ageing and Development·K R McCormick, J L Haar
Jul 1, 1991·The American Journal of Anatomy·K R McCormick, J L Haar
Sep 10, 2019·Aging Cell·Gregory M FahySteve Horvath


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Related Concepts

Thymic Epithelial Cell
Mice, Inbred CBA
TC2 Cells
Cell Motility
Neoplasm of Uncertain or Unknown Behavior of Thymus
Squamous Transitional Epithelial Cell Count
CBA/J Mouse
Disease of Thymus Gland

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