PMID: 6106784Sep 27, 1980Paper

Enhanced in-vivo platelet release reaction, increased thromboxane synthesis, and decreased prostacyclin release after tourniquet ischaemia

Lancet
J ZahaviV V Kakkar

Abstract

Plasma beta-thromboglobulin (beta-TG), a marker of in-vivo platelet release reaction, was measured in 27 meniscectomy patients, 10 patients who underwent total knee replacements (TKR) (both procedures performed under tourniquet ischaemia), and 10 herniorrhaphy patients. In 22 meniscectomy and 7 TKR patients plasma-thromboxane-B2 (TxB2), a stable end-product of thromboxane-synthetase activity, was also determined. The mean plasma beta-TG and TxB2 had risen significantly within 5 min of release of the tourniquet, indicating increased in-vivo platelet release reaction and prostaglandin synthesis in these patients. In the herniorrhaphy patients beta-TG and TxB2 did not alter significantly postoperatively. In 6 pigs (weighing 20-30 kg) who underwent meniscectomy under tourniquet ischaemia plasma TxB2 rose significantly 15-30 min after release of the tourniquet, and prostacyclin release was significantly lower from veins exposed to ischaemia than from control veins. Large de-endothelialised areas were seen on scanning electron-micrographic sections of affected veins, and these areas were covered with a monolayer of platelets and platelet clumps. These changes associated with tourniquet ischaemia may explain the high incidence of veno...Continue Reading

References

Sep 1, 1977·Scandinavian Journal of Clinical and Laboratory Investigation·A C Teger-NilssonE Gyzander
Sep 1, 1979·British Journal of Haematology·G CellaV V Kakkar
Jun 1, 1978·Pharmacological Research Communications·A SzczeklikJ Mruk
Apr 1, 1979·Prostaglandins and Medicine·R I LewyL Wiener
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Feb 1, 1980·Thrombosis Research·J ZahaviV V Kakkar

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Citations

Aug 1, 1986·Agents and Actions·F De Clerck
Nov 15, 2006·Archives of Orthopaedic and Trauma Surgery·Aki FukudaAtsumasa Uchida
Apr 4, 1998·Journal of Clinical Anesthesia·T AkataS Takahashi
Feb 21, 1981·British Medical Journal·J R Mitchell
Dec 1, 1995·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·J S WilliamsG Dorfman
Jun 1, 1982·Cephalalgia : an International Journal of Headache·W K Amery
Jun 5, 2003·The Journal of Trauma·Raimo OjanenHeikki Vapaatalo
Jul 1, 1985·Stroke; a Journal of Cerebral Circulation·A B ShahB M Coull
Mar 8, 2014·Journal of Orthopaedic Surgery and Research·Wei ZhangLiaobin Chen

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