PMID: 1521921May 1, 1992Paper

Enhanced induction of lymphokine-activated killer activity after lentinan administration in patients with gastric carcinoma

International Journal of Immunopharmacology
S ArinagaT Akiyoshi

Abstract

In 15 patients with gastric carcinoma, peripheral blood mononuclear cells (PBM) were obtained serially before and 3, 5 and 7 days after lentinan administration. The generation of lymphokine-activated killer (LAK) activity, induced by in vitro activation of PBM with interleukin 2 (IL 2), was significantly augmented 5 days after a single intravenous dose of 2 mg lentinan, when compared with that before lentinan injection. Natural killer (NK) activity of PBM was also significantly enhanced 7 days after the drug injection. However, the distribution of lymphocyte subsets exhibited no significant change following lentinan administration.

References

Jan 1, 1988·Immunopharmacology and Immunotoxicology·G PéterY Kaneko
Feb 15, 1981·International Journal of Cancer. Journal International Du Cancer·M J BrundaH T Holden
Mar 15, 1980·International Journal of Cancer. Journal International Du Cancer·J ZákányJ Fachet

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Citations

Jan 1, 1994·Cancer Investigation·R C Turowski, P L Triozzi
Aug 21, 2010·The Journal of Pharmacy and Pharmacology·Ni LiJian-Qing Gao
Jul 15, 2004·Oncology Nursing Forum·Muriel J Montbriand

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