Enhanced infection of avian influenza virus H9N2 with infectious laryngeotracheitis vaccination in chickens

Veterinary Microbiology
Nagah ArafatReham A El-Shafei

Abstract

Avian influenza and infectious laryngeotracheitis viruses are common causes of respiratory diseases in chickens with economical importance worldwide. In this study, we investigated the effect of experimental co-infection of avian influenza virus-H9N2 (AIV-H9N2) with infectious laryngeotracheitis virus (ILTV) live-attenuated vaccine (LAR-VAC®) on chickens. Four experimental groups were included in this study: negative control group, AIV-H9N2 group, AIV-H9N2+LAR-VAC® group, and LAR-VAC® group. AIV-H9N2 was inoculated intranasally to challenged groups at 35 days of age. On the same day, LAR-VAC® was ocularly administered to vaccinated groups. Chickens were observed for clinical signs, changes in body weight and mortality rates. Tissue samples, sera, tracheal and cloacal swabs, and blood were also collected at 3, 6, 9 and 12 days post-infection (PI). A significant increase in clinical signs and mortality rates were observed in the AIV-H9N2 + LAR-VAC® group. Moreover, chickens coinfected with AIV-H9N2 and LAR-VAC® showed a significant decrease in body weight and lymphoid organs indices. The tracheal gross and histopathological lesions and the shedding titer and period of AIV-H9N2 were significantly higher in AIV-H9N2 + LAR-VAC® grou...Continue Reading

Citations

Sep 27, 2018·EFSA Journal·UNKNOWN European Food Safety AuthorityFrancesca Baldinelli
May 31, 2019·Avian Pathology : Journal of the W.V.P.A·Joseph A AwuniIsabella Monne
Aug 25, 2020·Avian Pathology : Journal of the W.V.P.A·Nagah ArafatAbdelfattah H Eladl
Oct 18, 2020·Animals : an Open Access Journal From MDPI·Shaimaa TalatWael K Elfeil
Oct 28, 2019·Veterinary Microbiology·Abdelfattah H EladlMohamed A Saif
Jul 23, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Richa SoodVijendra Pal Singh

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