Enhanced inhibitive effects of combination of rofecoxib and octreotide on the growth of human gastric cancer

International Journal of Cancer. Journal International Du Cancer
Chengwei TangChun-Hui Wang

Abstract

Our previous studies indicated that cyclooxygenase-2 inhibitor or octreotide could suppress the proliferation of gastric adenocarcinoma in vitro or in vivo. The present study was aimed to find whether rofecoxib combined with octreotide could enhance the inhibitive effects on the growth of gastric cancer. The effect of rofecoxib or octreotide on proliferation of gastric cancer cell line was determined by 3H-thymidine ribotide incorporation. The TdT-mediated dUTP nick end-labeling assay was used to detect the apopotosis. To determine their synergic antineoplastic effects, the interaction between rofecoxib and octreotide on SGC-7901 cell was evaluated by the median effect plot. After orthotopical implantion of xenografts of human gastric cancer in stomach, nude mice were given rofecoxib plus octreotide for 8 weeks. Cyclooxygenase-2 in gastric cancer tissues was measured by immunohistochemistry. Combination of rofecoxib and octreotide presented synergistic effect (combination index < 1) in the majority of responses. The inhibitory rate for xenografts in nude mice was 89.7% in rofecoxib group. Combination of rofecoxib and octreotide enhanced inhibitory rate to 98.8%. The combination greatly increased the apoptotic index (78.20% +/- ...Continue Reading

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Citations

Jun 8, 2006·Journal of the National Cancer Institute·Sabine GröschGerd Geisslinger
Aug 18, 2010·Pathology International·Hiroko Oshima, Masanobu Oshima
Mar 12, 2013·International Journal of Peptides·Federica BarbieriTullio Florio
Oct 25, 2011·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Hee Sung KimWoo Ho Kim
May 12, 2009·Journal of Digestive Diseases·Chun Hui WangCheng Wei Tang
Oct 30, 2014·Molecular Medicine Reports·Xiao-Qian ZhangZhi-Xing Gao
Jul 6, 2014·Oncology Reports·Hong-Gang XiangLei Chen

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