Enhanced inhibitory effects of TBT chloride on the development of F1 rats

Archives of Environmental Contamination and Toxicology
H AsakawaY Aizawa

Abstract

Neurotoxicity is one of the major effects of tributyltin (TBT). The effects on the next generation of F(1) rats exposed to TBT via the placenta and their dams' milk may be stronger than those on adults. Pregnant Wister rats were exposed to TBT at 0 and 125 ppm in their food. Half of the female F(1) rats in both groups were exposed to TBT at 125 ppm in their food from 9 to 15 weeks of age. Female F(1) rats were divided into the following groups: the control-control (CC) group, with no exposure; the TBT-control (TC) group, exposed to TBT via the placenta and their dams' milk; the control-TBT (CT) group, exposed to TBT via their food from 9 to 15 weeks of age; and the TBT-TBT (TT) group, exposed to TBT via the placenta, their dams' milk, and their food (n = 10/group). After administration, an open-field test and prepulse inhibition (PPI) test were performed at 15 weeks of age. The mean body weights of the TC and TT groups were significantly lower than that of the CC group from 9 to 15 weeks of age. The mean relative thymus weight of the TC and TT groups was significantly lower than that of the CC group. In the open-field test, a marked decrease in the total locomotion distance was observed in the TT group. The mean values in the T...Continue Reading

References

Jun 24, 2005·Bioscience, Biotechnology, and Biochemistry·Kimiko KimuraYoshiko Sugita-Konishi
Oct 22, 2008·Journal of Environmental Management·Pei-Jie MengLi-Lian Liu
Nov 1, 2005·Environmental Health and Preventive Medicine·Nobuhiro KonnoYoshiko Sugita-Konishi

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Citations

Dec 12, 2012·Reproductive Toxicology·Jones Bernardes GraceliMarcos Antonio Dos Santos Fernandez
Mar 16, 2018·Journal of Perinatal Medicine·Yuko AritaMorgan R Peltier
Jan 25, 2011·The Mount Sinai Journal of Medicine, New York·Michele La Merrill, Linda S Birnbaum
Mar 29, 2013·Metallomics : Integrated Biometal Science·Shigeru YamadaYasunari Kanda
Jul 19, 2018·Trends in Endocrinology and Metabolism : TEM·Almudena Veiga-LopezVasantha Padmanabhan

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