PMID: 2510239Jan 1, 1989Paper

Enhanced interferon-gamma production by lymphocytes induced by a mitogen from mycoplasma arthritidis in patients with ankylosing spondylitis

Rheumatology International
M SeitzH Kirchner

Abstract

We have examined proliferation of and interferon-gamma (IFN-gamma) production by peripheral blood lymphocytes induced by a purified mitogen derived from mycoplasma arthritidis (MAS) in patients with seronegative spondylo-arthropathies and healthy individuals. In all patients and healthy controls MAS exerted a potent nonspecific lymphoproliferation. In contrast, only patients with ankylosing spondylitis (ASp) showed a strong IFN-gamma production after stimulation with MAS. The maximal IFN-gamma response was observed in HLA-B27+/HLA-DQw3+ patients. However, healthy controls with the HLA-DQw3 haplotype with or without the presence of HLA-B27 exhibited also a slight but statistically not significant increase of IFN-gamma production. Moreover, in this study we have found an enhanced frequency of HLA-DQw3 in patients with ASp and reactive arthritis. This immunogenetic association explains the enhanced lymphocyte reactivity in these inflammatory rheumatic disorders to mycoplasmal antigens.

References

Dec 1, 1979·Arthritis and Rheumatism·B C Cole, G H Cassell
Jul 1, 1976·Infection and Immunity·B C ColeL A Glasgow
Sep 1, 1986·Scandinavian Journal of Immunology·H KirchnerF Herbst
Jun 22, 1974·Lancet·H O McDevitt, W F Bodmer
Jul 1, 1973·Annals of the Rheumatic Diseases·J M Moll, V Wright

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