Enhanced invasiveness of bovine-derived neonatal sequence type 17 group B streptococcus is independent of capsular serotype

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Nicola JonesOxford Group B Streptococcus Consortium

Abstract

A defined geographical area (Oxford, United Kingdom) was investigated for the role of group B Streptococcus (GBS) as a human pathogen. GBS carriage in pregnant women and invasive disease in neonates and adults >60 years of age was studied over a 3-year period. Multilocus sequence typing and capsular serotyping were used to study 369 isolates of GBS from carriage in pregnant women (n=190) and invasive disease in neonates (n=109) and adults >60 years of age (n=70). A total of 20.3% of pregnant women carried GBS. Invasive GBS disease occurred at a rate of 0.9 cases per 1000 live births and 11 cases per 100,000 population >60 years of age per annum. Four sequence types (STs) (ST-17, ST-19, ST-23, and ST-1) that were identified with use of multilocus sequence typing accounted for >50% of carried and invasive strains. A single sequence type (ST-17), previously shown to be phylogenetically of bovine origin, was significantly associated with increased invasiveness in neonates (P=.00002), and this was independent of capsular serotype III. In contrast, among adults >60 years of age, no STs exhibited increased invasiveness, compared with STs carried in pregnant women. Enhanced invasiveness associated with ST-17 is specific to neonates and...Continue Reading

References

Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J M MusserR K Selander
Jan 1, 1986·The Journal of Infection·M J HastingsR P Rivers
Dec 1, 1973·The Journal of Pediatrics·C J Baker, F F Barrett
Mar 1, 1983·British Journal of Obstetrics and Gynaecology·C S EasmonJ Stringer
Apr 1, 1994·Computer Applications in the Biosciences : CABIOS·S KumarM Nei
Mar 1, 1996·Infection·H M HasselhornF W Tiller
Jun 1, 1996·Molecular Biotechnology·R Staden
Apr 16, 1998·The Journal of Infectious Diseases·S TakahashiJ F Bohnsack
Mar 10, 2001·The Journal of Infectious Diseases·K J HenningUNKNOWN Maryland Emerging Infections Program
Jul 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M M Farley
Dec 12, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sandra J BlissBetsy Foxman
Aug 30, 2002·Proceedings of the National Academy of Sciences of the United States of America·Herve TettelinClaire M Fraser
Apr 19, 2003·Emerging Infectious Diseases·Outi LyytikäinenAnna-Liisa Järvenpää
Jun 7, 2003·Journal of Clinical Microbiology·Nicola JonesBrian G Spratt
Jul 11, 2003·The Journal of Infectious Diseases·Feng-Ying C LinKaren Adams
Sep 6, 2003·Journal of Clinical Microbiology·H-C SlotvedH B Konradsen
Jan 31, 2004·Lancet·Paul T HeathUNKNOWN PHLS Group B Streptococcus Working Group
Mar 5, 2004·The Journal of Infectious Diseases·H Dele DaviesCarol J Baker
May 6, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Abbie M WeisnerAndroulla Efstratiou
May 8, 2004·Journal of Clinical Microbiology·Naiel BisharatNicola Jones
Jan 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Morven S EdwardsCarol J Baker

❮ Previous
Next ❯

Citations

Oct 5, 2011·Journal of Mammary Gland Biology and Neoplasia·Ruth N ZadoksYnte H Schukken
Oct 30, 2013·The Journal of Biological Chemistry·Ho Seong SeoPaul M Sullam
Oct 20, 2010·The Journal of Experimental Medicine·Asmaa TaziClaire Poyart
May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shannon D ManningH Dele Davies
Jun 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shannon D ManningH Dele Davies
Mar 22, 2012·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Shaynoor DramsiMichel-Yves Mistou
Jul 22, 2011·The Pediatric Infectious Disease Journal·Kirsten FlueggeReinhard Berner
Jul 8, 2009·Journal of Bacteriology·A Cody SpringmanShannon D Manning
Dec 22, 2009·Journal of Bacteriology·Elisabete Raquel MartinsMário Ramirez
Jul 9, 2010·Journal of Clinical Microbiology·Michelle J DiedrickPatricia Ferrieri
Dec 26, 2008·Journal of Clinical Microbiology·Mathieu BrochetPhilippe Glaser
Aug 19, 2007·Journal of Clinical Microbiology·E R MartinsUNKNOWN Portuguese Group for the Study of Streptococcal Infections
Aug 26, 2011·Journal of Clinical Microbiology·Charlotte A HuberGunturu Revathi
Jan 23, 2009·Journal of Clinical Microbiology·Shannon D ManningH Dele Davies
Oct 2, 2008·Emerging Infectious Diseases·Claire PoyartPatrick Trieu-Cuot
Jan 1, 2008·Interdisciplinary Perspectives on Infectious Diseases·Lixin ZhangBetsy Foxman
Jan 29, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Mary MeehanMary Cafferkey
Aug 30, 2013·Vaccine·Kirsty Le Doare, Paul T Heath
Dec 22, 2009·American Journal of Infection Control·Jennifer K MacFarquharWilliam Schaffner
Apr 9, 2011·Journal of Medical Microbiology·Carlos FlorindoMaria J Borrego
Jun 29, 2012·Journal of Medical Microbiology·Aruni de ZoysaAndroulla Efstratiou
Mar 26, 2010·The Biochemical Journal·Shannon WeimanAmanda L Lewis
Jan 15, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Z ZhaoG L Gilbert
Dec 3, 2014·Journal of Microbiological Methods·Anne Karin BrigtsenAndrew Whitelaw
Apr 21, 2012·Gynecologic and Obstetric Investigation·Yen-Ying MaHao Lin
Dec 7, 2017·Frontiers in Immunology·Julia Kolter, Philipp Henneke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.