Enhanced learning deficits in female rats following lifetime pb exposure combined with prenatal stress.

Toxicological Sciences : an Official Journal of the Society of Toxicology
Deborah A Cory-SlechtaSue Liu

Abstract

Pb (lead) exposure and stress are co-occurring risk factors (particularly in low socioeconomic communities) that also act on common biological substrates and produce common adverse outcomes, including cognitive impairments. This study sought to determine whether lifetime Pb exposure combined with prenatal stress would enhance the cognitive deficits independently associated with each of these risk factors and to explore associated mechanisms of any observed impairments. Learning was evaluated using a multiple schedule of repeated learning and performance in female rats subjected to lifetime Pb exposure (0 or 50 ppm Pb in drinking water beginning in dams 2 months prior to breeding; blood Pb levels ∼10 μg/dl), to prenatal restraint stress on gestational days 16 and 17, or to both. Blood Pb, corticosterone levels, brain monoamines, and hippocampal nerve growth factor levels were also measured. Sequence-specific learning deficits produced by Pb, particularly the number of responses to correctly learn response sequences, were further enhanced by stress, whereas performance measures were unimpaired. Statistical analyses indicated significant relationships among corticosterone levels, frontal cortex dopamine (DA), nucleus accumbens dop...Continue Reading

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Citations

Aug 10, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joseph V Rodricks, Jonathan I Levy
Aug 30, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Deborah A Cory-SlechtaKatherine Conrad
Jan 30, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Deborah A Cory-SlechtaJoshua L Allen
Aug 15, 2012·Environmental Health Perspectives·Michelle L Bell, Keita Ebisu
Oct 23, 2012·Environmental Health Perspectives·Eric E BeierJ Edward Puzas
Jun 28, 2011·Arhiv za higijenu rada i toksikologiju·Rajashekar Rao BarkurLaxminarayana K Bairy
Dec 19, 2012·Epigenomics·Marie-Claude SenutDouglas Ruden
Apr 3, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joshua L AllenDeborah A Cory-Slechta
Nov 7, 2014·Environmental Health : a Global Access Science Source·Jessie L C ShmoolJane E Clougherty
Jul 8, 2015·American Journal of Community Psychology·Jessie L C ShmoolJane E Clougherty
Apr 7, 2016·Neurotoxicology and Teratology·Andrew D KraftSusan L Makris
Nov 29, 2015·Human & Experimental Toxicology·W UtembeM Gulumian
Feb 27, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marissa SobolewskiDeborah A Cory-Slechta
Dec 14, 2018·International Journal of Environmental Research and Public Health·Devon C Payne-SturgesJane E Clougherty
Apr 18, 2018·Frontiers in Genetics·Garima SinghJay S Schneider
Mar 11, 2021·Environmental Health Perspectives·Devon C Payne-SturgesPeter S Hovmand

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