Enhanced levels of biochemical markers for cobalamin deficiency in totally gastrectomized rats: uncoupling of the enhancement from the severity of spongy vacuolation in spinal cord

Experimental Neurology
Giuseppe ScalabrinoJ Lindenbaum

Abstract

The totally gastrectomized (TGX) rat is a new experimental model for studying the pathogenesis of cobalamin (Cbl)-deficient myelopathy, i.e., subacute combined degeneration, total gastrectomy (TG) serving as a surgical paradigm of human pernicious anemia. We determined the serum levels of some biochemical indicators of Cbl deficiency in TGX rats at 2 to 10 months after TG. Methylmalonic acid (MMA) rose within 2 months and progressively increased thereafter until the end of the investigation period. 2-Methylcitric acid (MCA) rose significantly by 6 months and showed a further increment 4 months later. Homocysteine was only clearly elevated much later than the serum MMA, i.e., 10 months after the operation. The concentrations of MMA, MCA, and cystathionine were increased in kidney, liver, and spinal cord (SC) of TGX rats at 10 months. Chronic treatment of TGX rats with Cbl greatly decreased the serum levels of all the metabolic indicators of Cbl deficiency. Chronic peroral administration of the antibiotic lincomycin to TGX rats in an attempt to suppress the enteric flora markedly decreased serum MMA levels. Only Cbl, however, given either for the first 2 months after TG or for the third and fourth postoperative months (i.e., afte...Continue Reading

References

Jan 1, 1992·Annual Review of Nutrition·J Metz
Jul 1, 1991·Medicine·E B HealtonJ Lindenbaum
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Citations

Jul 21, 2000·Annals of Surgery·S AdachiK Fukao
Sep 11, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Laurent BrunaudJean-Louis Guéant
Dec 6, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe ScalabrinoElena Mutti
Oct 20, 2015·Journal of the Neurological Sciences·Daniela Veber, Giuseppe Scalabrino
Nov 22, 2011·Muscle & Nerve·Giuseppe ScalabrinoGiovanni Tredici
Oct 6, 2009·Journal of Neurochemistry·Giuseppe Scalabrino
May 13, 2006·Trends in Molecular Medicine·Giuseppe Scalabrino, Maddalena Peracchi
Dec 15, 2005·Neuroscience Letters·Giuseppe ScalabrinoGiovanni Tredici
Sep 23, 2014·The International Journal of Biochemistry & Cell Biology·Giuseppe ScalabrinoGiovanni Tredici
Nov 26, 2011·Experimental Neurology·Giuseppe ScalabrinoGiovanni Tredici
Apr 20, 2007·Archives of Biochemistry and Biophysics·Seema KalraBellur Seetharam
Jul 12, 2002·Journal of Neuroscience Research·Gaetano CairoGiuseppe Scalabrino
Jan 10, 2008·Journal of Neuroscience Research·Daniela VeberGiuseppe Scalabrino
Nov 2, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G ScalabrinoG Pravettoni
Mar 29, 2001·Journal of Neuropathology and Experimental Neurology·G Scalabrino
Feb 11, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·F R BuccellatoG Scalabrino
May 26, 2010·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Amália Cínthia Meneses RêgoAldo Cunha Medeiros
Apr 2, 2020·Italian Journal of Pediatrics·Cezary DubajWanda Furmaga-Jabłońska
Nov 25, 2004·Annals of Neurology·Giuseppe ScalabrinoMaddalena Peracchi

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