Enhanced localized plasmonic detections using partially-embedded gold nanoparticles and ellipsometric measurements.

Biomedical Optics Express
Rakesh Singh MoirangthemYia-Chung Chang

Abstract

A cost-effective, stable and ultrasensitive localized surface plasmon resonance (LSPR) sensor based on gold nanoparticles (AuNPs) partially embedded in transparent substrate is presented. Partially embedded AuNPs were prepared by thermal annealing of gold thin films deposited on glass at a temperature close to the glass transition temperature of the substrate. Annealed samples were optically characterized by using spectroscopic ellipsometry and compare with theoretical modeling to understand the optical responses from the samples. By combining the partially-embedded AuNPs substrate with a microfluidic flow cell and dove prism in an ellipsometry setup, an ultrasensitive change in the LSPR signal can be detected. The refractive index sensitivity obtained from the phase measurement is up to 1938 degrees/RIU which is several times higher than that of synthesized colloidal gold nanoparticles. The sample is further used to investigate the interactions between primary and secondary antibodies. The bio-molecular detection limit of the LSPR signal is down to 20 pM. Our proposed sensor is label free, non-destructive, with high sensitivity, low cost, and easy to fabricate. These features make it feasible for commercialization in biomedica...Continue Reading

References

Jul 18, 2001·Journal of the American Chemical Society·G KalyuzhnyI Rubinstein
Sep 1, 2004·Analytical and Bioanalytical Chemistry·Amanda J Haes, Richard P Van Duyne
Jul 21, 2006·The Journal of Physical Chemistry. B·Molly M Miller, Anne A Lazarides
May 24, 2008·Nature Materials·Jeffrey N AnkerRichard P Van Duyne
Aug 30, 2008·Analytical Chemistry·Tatyana A BendikovIsrael Rubinstein
Jun 16, 2010·Biosensors & Bioelectronics·Rakesh Singh MoirangthemPei-Kuen Wei
Mar 4, 2011·Optics Letters·Rakesh Singh MoirangthemPei-Kuen Wei
Jun 9, 2011·Chemical Reviews·Kathryn M Mayer, Jason H Hafner
May 19, 2011·The Journal of Physical Chemistry Letters·Ofer KedemIsrael Rubinstein

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Citations

Sep 1, 2015·Advances in Colloid and Interface Science·Olena MaddenPatrick G Murray
Jun 17, 2014·Sensors·Jayan Ozhikandathil, Muthukumaran Packirisamy
Sep 29, 2019·Nanomaterials·Petr Otipka, Jaroslav Vlček
Jan 7, 2016·Beilstein Journal of Nanotechnology·Htet H KyawJoydeep Dutta
Feb 28, 2016·Journal of Nanobiotechnology·Jesus ValdezShree Ram Singh
Sep 4, 2020·Materials·Mikko HongistoLaeticia Petit
Jul 13, 2021·Nano Letters·Mariachiara ManoccioAdriana Passaseo

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Methods Mentioned

BETA
surface plasmon resonance
biosensor
chip
biosensing
bio-chip

Software Mentioned

EMA
Rsoft
GRANFILM
WVASE32

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