PMID: 8938126Nov 1, 1996Paper

Enhanced LTP in mice deficient in the AMPA receptor GluR2

Neuron
Zhengping JiaJ C Roder

Abstract

AMPA receptors (AMPARs) are not thought to be involved in the induction of long-term potentiation (LTP), but may be involved in its expression via second messenger pathways. However, one subunit of the AMPARs, GluR2, is also known to control Ca2+ influx. To test whether GluR2 plays any role in the induction of LTP, we generated mice that lacked this subunit. In GluR2 mutants, LTP in the CA1 region of hippocampal slices was markedly enhanced (2-fold) and nonsaturating, whereas neuronal excitability and paired-pulse facilitation were normal. The 9-fold increase in Ca2+ permeability, in response to kainate application, suggests one possible mechanism for enhanced LTP. Mutant mice exhibited increased mortality, and those surviving showed reduced exploration and impaired motor coordination. These results suggest an important role for GluR2 in regulating synaptic plasticity and behavior.

References

Mar 23, 1992·FEBS Letters·M YamazakiM Mishina
Dec 1, 1989·Journal of Neuroscience Methods·M G BlantonA R Kriegstein
Jun 1, 1982·Neuroscience·R W TurnerJ J Miller
Jan 15, 1995·The Journal of Physiology·N SprustonB Sakmann
Jan 1, 1995·The Journal of Physiology·K A Clark, G L Collingridge
Jan 1, 1994·Annual Review of Neuroscience·M Hollmann, S Heinemann
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A NagyJ C Roder
Jan 7, 1993·Nature·T V Bliss, G L Collingridge

❮ Previous
Next ❯

Citations

Sep 16, 1999·Cellular and Molecular Life Sciences : CMLS·M D Krasowski, N L Harrison
Dec 30, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Shin Kwak, Yukio Kawahara
Jul 8, 2005·Psychopharmacology·Anja Murschall, Wolfgang Hauber
Jul 19, 2006·Cell and Tissue Research·Laurent Groc, Daniel Choquet
Aug 10, 2006·Cell and Tissue Research·Rolf Sprengel
Jul 10, 2004·Journal of Physiology, Paris·Jean Christophe Poncer
Dec 20, 2000·Brain Research·H TanakaR S Zukin
Sep 22, 2001·Physiology & Behavior·A V AnagnostopoulosM T Davisson
Aug 12, 2003·Cell Calcium·Mark Arundine, Michael Tymianski
Aug 2, 2001·Trends in Pharmacological Sciences·H Zhu, G A Barr
Oct 24, 2001·Trends in Neurosciences·C Lüscher, M Frerking
Feb 1, 2000·Trends in Neurosciences·T R Soderling, V A Derkach
Mar 20, 2003·Behavioural Brain Research·Gernot RiedelJacques Micheau
Oct 1, 1998·Behavioural Brain Research·R GerlaiZ Jia
Aug 28, 2003·Neuroscience Research·Graham L Collingridge, John T R Isaac
Oct 31, 1998·Brain Research. Molecular Brain Research·L K Friedman, J Velísková
Apr 2, 1999·Brain Research. Molecular Brain Research·T NishizakiK Sumikawa
Apr 12, 2003·Neurochemistry International·Linda K FriedmanJana Velísková
Aug 31, 2001·Progress in Neurobiology·N Kemp, Z I Bashir
Apr 29, 1998·Progress in Neurobiology·S OzawaK Tsuzuki
Dec 1, 1998·Neuroscience Letters·C J McNairD J Maxwell
Oct 9, 1999·Epilepsy Research·B S MeldrumA G Chapman
Feb 7, 2001·Current Opinion in Neurobiology·J Z Tsien
Jun 14, 2000·Current Opinion in Neurobiology·R MalinowY Hayashi
Jun 7, 2002·Current Opinion in Neurobiology·Michael F Barry, Edward B Ziff
May 6, 1998·Current Opinion in Neurobiology·G W Davis, C S Goodman
Jan 25, 2014·Nature Communications·Li Shen LooWanjin Hong
Aug 31, 2010·Nature Neuroscience·Danielle M EversDaniel T S Pak
May 17, 2005·Nature Neuroscience·Siqiong June Liu, Stuart G Cull-Candy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.