Enhanced Luminescent Properties of Photo-Stable Copper Nanoclusters through Formation of "Protein-Corona"-Like Assemblies

Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry
Nirmal Kumar DasSaptarshi Mukherjee

Abstract

In this study, interactions of synthesized copper nanoclusters (CuNCs) with a model transport protein, human serum albumin (HSA), have been systematically investigated by using various spectroscopic approaches. The interactions give rise to the formation of "protein-corona" like assemblies and the luminescence properties (both steady-state and time-resolved) are enhanced due to gradual adsorption of the protein on the surface of the NCs. The associated thermodynamics and binding parameters have been estimated resorting to luminescent experimental techniques as well as isothermal titration calorimetry (ITC) studies, indicating that every NC is surrounded by (4±1) protein molecules. The adsorption of HSA on the surface of the NCs has been characterized by dynamic light scattering (DLS) and time-resolved anisotropy measurements. Finally, fluorescence correlation spectroscopy (FCS) data substantiate the emergence of new "protein-corona" like assemblies resulting in slower translational diffusion motions and concomitant rise of the hydrodynamic diameters.

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Citations

Jan 28, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Amit AkhuliMoloy Sarkar
May 12, 2021·Journal of Molecular Recognition : JMR·Robert J FalconerAnthony K Mittermaier
Apr 5, 2019·The Journal of Physical Chemistry. B·Atanu NandySaptarshi Mukherjee
Dec 9, 2021·Chemical Communications : Chem Comm·Subhajit Chakraborty, Saptarshi Mukherjee

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