Enhanced natural killer cell activity in experimental murine encephalitozoonosis.

Infection and Immunity
J Y NiederkornE Mayhew

Abstract

Spleen cells from mice infected with the protozoan parasite Encephalitozoon cuniculi demonstrated enhanced in vitro cytolysis of YAC-1 lymphoma cells. Selective cell depletion experiments showed that the dominant cell population mediating cytolysis of YAC-1 tumor cells expressed the characteristic phenotype of murine natural killer (NK) cells because (i) pretreatment of spleen cells with anti-asialo GM 1 antiserum plus complement abolished the cytotoxic activity; (ii) augmented cytolysis was found in athymic nude mice; (iii) pretreatment of spleen cells with anti-Thy 1.2 plus complement did not affect the level of cytolysis; and (iv) nylon wool removal of adherent cells did not reduce the augmented cytolysis. The augmented cytolysis peaked 7 days after infection, gradually diminished, and finally returned to control levels by 21 days postinfection. The parasite-induced augmentation of NK cell activity was dose-dependent: inoculation of 10(7) parasites gave maximum enhancement, whereas 10(5) or 10(4) parasites had an insignificant effect on spontaneous NK cell cytolysis. The augmented NK cell cytotoxicity was dependent upon viable parasites; inoculation of killed parasites failed to stimulate a significant increase in spontaneou...Continue Reading

References

Jan 1, 1977·The Journal of Experimental Medicine·L GlimcherH Cantor
Jan 1, 1978·Scandinavian Journal of Immunology·O A HallerH Wigzell
Jan 1, 1979·Immunological Reviews·R Kiessling, H Wigzell
Nov 1, 1978·The Journal of protozoology·J A Shadduck, M B Polley
May 1, 1977·The Journal of Experimental Medicine·O HallerH Wigzell
Jan 12, 1972·Nature: New Biology·J B HibbsJ S Remington
Apr 1, 1970·Canadian Journal of Microbiology·J E Bismanis
Apr 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·J A ArmstrongL Ople
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Oct 24, 1969·Science·J A Shadduck
May 28, 1981·Nature·C S HenneyS Gillis
Sep 1, 1981·The Journal of Experimental Medicine·N MinatoB R Bloom
Sep 1, 1981·The Journal of Infectious Diseases·J Y NiederkornE C Schmidt
Oct 2, 1981·Science·R B Herberman, J R Ortaldo

❮ Previous
Next ❯

Citations

Dec 1, 2011·FEMS Microbiology Reviews·Kaya Ghosh, Louis M Weiss
May 4, 2004·Acta Veterinaria Hungarica·Alexandra ValencákováLýdia Cisláková
Jul 17, 2020·Frontiers in Microbiology·Yinze HanZeyang Zhou
May 23, 2001·Microbes and Infection·I A KhanL M Weiss
Oct 1, 1994·Clinical Microbiology Reviews·R WeberR L Owen
Apr 1, 1989·Clinical Microbiology Reviews·J A Shadduck, E Greeley
Apr 15, 1984·Cellular Immunology·C E Kirkpatrick, J P Farrell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.