Enhanced neural reactivity and selective attention to threat in anxiety

Biological Psychology
S EldarYair Bar-Haim

Abstract

Attentional bias towards threat is implicated in the etiology and maintenance of anxiety disorders. We examined the neural correlates of threat bias in anxious and nonanxious participants to shed light on the neural chronometry of this cognitive bias. In this study, event-related potentials (ERPs) were recorded while anxious (n=23) and nonanxious (n=23) young adults performed a probe-discrimination task measuring attentional bias towards threat (angry) and positive (happy) face stimuli. Results showed an attention bias towards threat among anxious participants, but not among nonanxious participants. No bias to positive faces was found. ERP data revealed enhanced C1 amplitude (∼80 ms following threat onset) in anxious relative to nonanxious participants when cue displays contained threat faces. Additionally, P2 amplitude to the faces display was higher in the anxious relative to the nonanxious group regardless of emotion condition (angry/happy/neutral). None of the ERP analyses associated with target processing were significant. In conclusion, our data suggest that a core feature of threat processing in anxiety lies in functional perturbations of a brain circuitry that reacts rapidly and vigorously to threat. It is this over-act...Continue Reading

References

Aug 1, 1983·The Quarterly Journal of Experimental Psychology. A, Human Experimental Psychology·D Navon, B Margalit
Jan 1, 1995·Psychophysiology·G R Mangun
Jul 1, 1996·Psychological Bulletin·J M WilliamsC MacLeod
Jan 1, 1997·Behaviour Research and Therapy·A T Beck, D A Clark
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·S A Hillyard, L Anllo-Vento
Aug 14, 1998·Behaviour Research and Therapy·K Mogg, B P Bradley
Nov 4, 2000·Trends in Cognitive Sciences·S J LuckE K Vogel
Feb 24, 2001·Journal of Abnormal Psychology·A Mathews, B Mackintosh
Mar 27, 2001·The European Journal of Neuroscience·P Krolak-SalmonF Mauguière
May 12, 2001·Psychophysiology·M JunghöferP J Lang
Jan 18, 2002·Experimental Brain Research·John J Foxe, Gregory V Simpson
Feb 5, 2003·Psychological Science·Harald T SchuppAlfons O Hamm
Apr 8, 2003·Cerebral Cortex·Francesco Di RussoSteven A Hillyard
May 3, 2003·Neuroscience Letters·Marcus StreitAndreas Ioannides
Oct 17, 2003·Brain Research. Cognitive Brain Research·Magali Batty, Margot J Taylor
Mar 3, 2004·Journal of Abnormal Psychology·Karin MoggBrendan P Bradley
Apr 1, 2004·Cerebral Cortex·Gilles PourtoisPatrik Vuilleumier
Jun 30, 2004·Emotion·Harald T SchuppAlfons O Hamm
Apr 27, 2005·Human Brain Mapping·Shimin FuRaja Parasuraman
May 28, 2005·Brain and Cognition·Yair Bar-HaimShlomit Glickman
Jan 5, 2007·Psychological Bulletin·Yair Bar-HaimMarinus H van IJzendoorn
May 13, 2008·Behaviour Research and Therapy·Sarah M HelfinsteinNathan A Fox
Aug 30, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel S PineNathan A Fox
Dec 17, 2008·Psychological Medicine·E M MuellerD A Pizzagalli
Jan 10, 2009·Behavior Genetics·Yong-Ku KimHo-Kyoung Yoon
Jan 15, 2009·Developmental Neuropsychology·Tracy A DennisChao-Cheng Chen
Feb 19, 2009·Journal of Abnormal Psychology·Ernst H W KosterColin MacLeod
Feb 19, 2009·Journal of Abnormal Psychology·Norman B SchmidtKiara R Timpano
Feb 19, 2009·Journal of Abnormal Psychology·Nader AmirJessica Bomyea
Jul 1, 2009·Psychiatry Research·Nim TottenhamCharles Nelson
Jul 25, 2009·Psychological Medicine·S Eldar, Y Bar-Haim
May 12, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Yair Bar-Haim

❮ Previous
Next ❯

Citations

Feb 15, 2011·Journal of Abnormal Child Psychology·Koraly Pérez-EdgarNathan A Fox
Jul 3, 2013·Brain and Cognition·Mandy RossignolPierre Philippot
Dec 12, 2012·Cognition & Emotion·Vandana AspenJames Lock
Sep 17, 2013·PloS One·Thibaud DumasNathalie George
Sep 18, 2014·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Yan ZhangHong Chen
Sep 16, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Brandon E GibbChristopher G Beevers
Jun 30, 2012·Journal of Neuroscience Methods·David J AcunzoMark C W van Rossum
Jun 5, 2012·Trends in Neurosciences·C M SylvesterE J Lenze
Nov 16, 2011·Brain and Cognition·Laura O'Toole, Tracy A Dennis
Oct 11, 2012·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Kathryn M HumMarc D Lewis
Dec 6, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jennifer C BrittonDaniel S Pine
Feb 13, 2014·The European Journal of Neuroscience·Emilie MeauxMagali Batty
Apr 12, 2016·Developmental Cognitive Neuroscience·Nhi ThaiKoraly E Pérez-Edgar
Jul 8, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Zhenhe ZhouYouhui Li
Sep 9, 2015·Frontiers in Psychology·María Isabel Núñez-Peña, Macarena Suárez-Pellicioni
Apr 5, 2011·Neuroscience Letters·Dong YangYan Song
Nov 24, 2012·Biological Psychology·Fredrik ÅhsJohan N Lundström
Feb 9, 2013·Journal of Behavior Therapy and Experimental Psychiatry·J G SuwayN A Fox
Jan 8, 2015·Frontiers in Psychology·Daniela M PfabiganUlrich S Tran
Jul 28, 2016·NeuroImage·Corinde E Wiers, Reinout W Wiers
Jan 17, 2017·Psychonomic Bulletin & Review·Rianne van RooijenMariska E Kret
Aug 1, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J TayamaS Shirabe
Nov 6, 2018·Psychological Science·John M Gaspar, John J McDonald
Nov 4, 2017·Scientific Reports·Caihong JiangLiang Zhang
Dec 30, 2016·Social Cognitive and Affective Neuroscience·Mareike BayerGilles Pourtois
Jan 31, 2018·Frontiers in Human Neuroscience·Laurent GrégoireIsabelle Blanchette
Apr 3, 2018·Journal of Abnormal Child Psychology·Michele BechorBethany C Reeb-Sutherland

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.