Enhanced neurobehavioral effects of cocaine with chronic neuroleptic exposure in rats

Schizophrenia Bulletin
Thomas R Kosten

Abstract

Individuals with schizophrenia are often treated with medications that block dopamine (DA) neurotransmission. Chronic administration of many DA antagonists alters dopaminergic function, causing a supersensitivity to DA agonists. Because the DA agonist properties of cocaine seem to be involved in its behavioral effects, chronic DA antagonist treatments may enhance these effects of cocaine. This article presents evidence to support this hypothesis, as well as its implications for treating schizophrenia patients who abuse cocaine and suggestions for future research.

Citations

Feb 20, 2008·Psychopharmacology·Margaret Haney, Roger Spealman
Sep 26, 2009·Psychopharmacology·Matthew W FeltensteinRonald E See
Mar 18, 2000·Clinical Psychology Review·J J BlanchardA R Sherwood
Apr 19, 2003·International Clinical Psychopharmacology·Stéphane PotvinJean-Yves Roy
Nov 24, 2004·Biological Psychiatry·Thomas R Kosten, Therese A Kosten
Jan 4, 2003·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Helen DermatisLaurence Westreich
Sep 14, 2007·European Addiction Research·Luis SanJose Martinez-Raga

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