PMID: 9170338May 1, 1997Paper

Enhanced nitric oxide release during cortical spreading depression following infusion of glyceryl trinitrate in the anaesthetized cat

Cephalalgia : an International Journal of Headache
S J ReadA A Parsons

Abstract

Intravenous infusion of glyceryl trinitrate (GTN) into migraineurs induces an immediate headache followed by migraine. We studied the effect of GTN (0.25 microgram kg-1 min-1) on local cerebrovascular laser Doppler flux (rCBFLDF), artery diameter and NO concentration (selective NO microelectrode) in the pial middle cerebral artery perfusion territory of the anaesthetized cat, at rest and during cortical spreading depression (SD). GTN infusion induced a significant increase in pial artery diameter, rCBFLDF, and NO concentration. Following termination of infusion, NO concentrations remained significantly elevated above controls for 60 min, other parameters returned to baseline within 10 min (p < 0.05, ANOVA, post hoc Dunnett's multiple comparison procedure). Two hours after termination of infusion KCl-evoked SD was initiated. GTN-treated animals exhibited significantly (p < 0.05, Kruskal-Wallis) elevated SD-induced NO release compared to controls. All other parameters remained unaffected. Our results demonstrate that GTN induces a prolonged increase in local NO concentrations and enhances SD-induced NO release.

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Citations

Aug 5, 1998·International Journal of Clinical & Laboratory Research·P MartellettiM Giacovazzo
Nov 16, 2013·CNS Drugs·Inger Jansen-OlesenJes Olesen
Dec 26, 2001·Brain Research. Brain Research Reviews·A Gorji
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Jun 6, 2002·Cephalalgia : an International Journal of Headache·C TassorelliG Nappi
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Mar 11, 2004·Cephalalgia : an International Journal of Headache·M Ashina
Jan 20, 2004·Cephalalgia : an International Journal of Headache·G SancesG Nappi
Oct 16, 2004·Cephalalgia : an International Journal of Headache·M AshinaJ Olesen
Aug 24, 2007·Cephalalgia : an International Journal of Headache·A GozalovJ Olesen
Apr 4, 2008·Cephalalgia : an International Journal of Headache·J M HansenM Ashina
Mar 12, 2010·BMC Neurology·Fabrizio VernieriClaudio Pedone
Jun 26, 2015·American Journal of Veterinary Research·Sanja KovacićGoran Ivkic
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Oct 21, 2010·Cephalalgia : an International Journal of Headache·J F TvedskovJ Olesen
Mar 28, 2012·Cephalalgia : an International Journal of Headache·Jes Olesen, Inger Jansen-Olesen
Aug 17, 1999·Cephalalgia : an International Journal of Headache·H KaubeP J Goadsby
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May 26, 2017·Headache·Narayan R Kissoon, Fred Michael Cutrer

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