PMID: 7543437Aug 1, 1995Paper

Enhanced nitric oxide synthase activity in portal hypertensive rabbits

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Paul A CahillJames V Sitzmann

Abstract

Portal hypertension (PHT) is characterized by splanchnic hyperemia caused by a reduction in mesenteric vascular resistance. Mediators of this hyperemia include nitric oxide (NO). This is based on several reports indicating a marked splanchnic hyporesponsiveness in PHT to vaso-constrictor stimuli, both in vitro and in vivo, and a subsequent reversal using specific inhibitors of NO synthase (NOS). The objective of this study was to determine directly if the generation of NO is altered in PHT vasculature. Thus, we compared NOS activity in the hyperemic vasculature of normal rabbits and rabbits with PHT (after undergoing partial portal vein ligation). Nicotinamide adenine dinucleotide phosphate diaphorase staining indicated the presence of NOS within the vascular endothelium. Ca(2+)-dependent NOS activity was significantly increased (P < .05) in PHT particulate fractions from the superior mesenteric artery and thoracic aorta, but not from the portal vein. There was no change in NOS activity within the cytosolic fractions. Arterial wall cyclic guanosine monophosphate (cGMP) levels and plasma nitrite levels were both significantly increased in PHT. These results show enhanced NOS activity in PHT hyperemic vessels concurrent with incr...Continue Reading

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Citations

Mar 1, 1996·Journal of Cellular Physiology·E M RedmondJ V Sitzmann
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M C HouJ V Sitzmann
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M OhtaI J Sarfeh
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A CahillJ V Sitzman
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N HoriR J Groszmann
Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J HellerD Lebrec
Aug 23, 2001·Pharmacology & Therapeutics·P A CahillJ V Sitzmann
Jan 1, 1997·Pharmacology & Therapeutics·P W Hadoke, P C Hayes
Aug 29, 1998·Journal of Hepatology·C M Fernández-RodriguezF Cuttitta
Sep 12, 2002·Nitric Oxide : Biology and Chemistry·Chang-Li WeiWei-Min Hon
Jan 13, 2001·British Journal of Pharmacology·S CalatayudJ V Esplugues
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E BarriereR Moreau
Jan 7, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Vijay Shah, Patrick S Kamath
Aug 26, 1998·The New England Journal of Medicine·P Y MartinR W Schrier
Jan 1, 1997·Journal of Clinical Gastroenterology·J G Ferraz, J L Wallace
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·Anne RabillerPhilippe Hervé
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Reiner Wiest, Roberto J Groszmann
Sep 22, 2001·Clinics in Liver Disease·V Shah
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V ShahR J Groszmann
Jan 28, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·E M RedmondJ V Sitzmann
Jun 26, 2001·Liver·R Farzaneh-Far, K Moore

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