PMID: 15353074Sep 9, 2004Paper

Enhanced oestradiol secretion briefly after embryo transfer in conception cycles from IVF

Reproductive Biomedicine Online
R R GrebL Kiesel

Abstract

The hypothesis was tested that conception cycles (CC) resulting from IVF can be distinguished from non-conception cycles (NC) by differences in corpora lutea function that are detectable at the earliest stage of embryo implantation. Luteal oestradiol secretion was analysed retrospectively in 409 ovarian stimulation cycles of 296 patients from the day of embryo transfer until 14 days after embryo transfer (ET+14) in IVF/intracytoplasmic sperm injection (ICSI) cycles. Human chorionic gonadotrophin (HCG) was administered in 330 of 409 cycles in addition to vaginal progesterone in all cycles. Differences in serum oestradiol concentrations between CC and NC increased from day ET+1 onward and became statistically significant on days ET+4 through ET+14, with higher oestradiol concentrations in CC compared with NC. Even though exogenous HCG administration prevented the fall in luteal oestradiol concentrations after ET+4 both in CC and NC, increasing differences in oestradiol concentrations between CC and NC after embryo transfer were observed in both groups of HCG-supplemented and non-supplemented cycles. It is concluded that luteal oestradiol secretion is affected at the earliest stage of embryo implantation. The putative early signal...Continue Reading

References

Feb 1, 1971·The Journal of Clinical Endocrinology and Metabolism·F W HansonV C Stevens
Apr 20, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·K Vicdan, A Zeki Isik
Sep 21, 2002·Molecular and Cellular Endocrinology·G KovalevskayaJ F O'Connor
Aug 21, 2003·Archives of Gynecology and Obstetrics·Erdal AktanOnur Bilgin

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Citations

Aug 5, 2014·Thyroid : Official Journal of the American Thyroid Association·Andrea BusnelliLuigi Fedele
Jun 19, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Barbara SonntagRobert R Greb
Jul 28, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Qiong WangCanquan Zhou
Oct 6, 2007·Endocrinology·Denise R Goldman-JohnsonJohn R Morrison

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