Enhanced oral bioavailability of EGCG using pH-sensitive polymeric nanoparticles: characterization and in vivo investigation on nephrotic syndrome rats

Drug Design, Development and Therapy
Guojuan Zhang, Jianfang Zhang

Abstract

Chronic kidney disease (CKD) is characterized by progressive loss of renal functions. At present, there are only limited therapeutic strategies to slow down the progress of CKD and there is an urgent need to develop new therapeutic strategies to treat CKD patients. Numerous research evidence supports the potential role of EGCG in the renal protection of CKD. However, the clinical use is still limited due to the poor oral bioavailability. The aim of this study was to develop pH-sensitive polymeric nanoparticles of EGCG to improve this deficiency. EGCG-loaded nanoparticles (EGCG NPs) were prepared by an improved emulsion evaporation method. The formulation prepared was in spherical with uniform sizes, high encapsulation efficiencies and drug loading. The therapeutic efficacy of EGCG NPs on chronic kidney disease was investigated on model of rat Nephrotic syndrome by measuring urinary protein excretion and kidney pathology score. The mean particle size was found to be 91.3±0.8 nm and the encapsulation efficiency% and drug loading% of the formulation were 80.8%±1.6% and 6.3%±1.4%, respectively. The powder X-ray diffraction and differential scanning calorimetry of EGCG NPs showed that EGCG existed in amorphous form in NPs. The relea...Continue Reading

Citations

May 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Changwei LiuSheng Zhang
Sep 27, 2019·Current Developments in Nutrition·Rattiyaporn Kanlaya, Visith Thongboonkerd
Jan 31, 2020·Frontiers in Bioengineering and Biotechnology·Alexander VaisermanOleh Lushchak
Jul 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saleh A AlmatroodiArshad Husain Rahmani
Nov 7, 2019·GeroScience·Oleh LushchakAlexander Vaiserman
Dec 2, 2020·Antioxidants·Zvezdelina Yaneva, Donika Ivanova

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Methods Mentioned

BETA
X-ray
differential
transmission electron microscopy
lavage
light microscopy

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