Enhanced Osseointegration of Hierarchical Micro/Nanotopographic Titanium Fabricated by Microarc Oxidation and Electrochemical Treatment

ACS Applied Materials & Interfaces
Guanglong LiXinquan Jiang

Abstract

Rapid osseointegration is recognized as a critical factor in determining the success rate of orthopedic and dental implants. Microarc oxidation (MAO) fabricated titanium oxide coatings with a porous topography have been proven to be a potent approach to enhance osteogenic capacity. Now we report two kinds of new hierarchical coatings with similar micromorphologies but different nanotopographies (i.e., MAO and MAO-AK coatings), and both coatings significantly promote cell attachment and osteogenic differentiation through mediating the integrin β1 signaling pathway. In this study, titanium with a unique hierarchical micro/nanomorphology surface was fabricated by a novel duplex coating process, that is, the first a titanium oxide layer was coated by MAO, and then the coating was electrochemically reduced in alkaline solution (MAO-AK). A series of in vitro stem cell differentiation and in vivo osseointegration experiments were carried out to evaluate the osteogenic capacity of the resulting coatings. In vitro, the initial adhesion of the canine bone marrow stem cells (BMSCs) seeded on the MAO and MAO-AK coatings was significantly enhanced, and cell proliferation was promoted. In addition, the expression levels of osteogenesis-relat...Continue Reading

References

Dec 4, 2003·Biomaterials·Lenka JonásováPeter Greil
Jan 17, 2004·International Dental Journal·Asbjørn JokstadAnn Wennerberg
Oct 20, 2005·Journal of Bioscience and Bioengineering·Fu LiuLiancheng Zhao
Mar 21, 2006·European Journal of Cell Biology·Elisabetta A Cavalcanti-AdamJoachim P Spatz
Aug 15, 2006·Dental Materials : Official Publication of the Academy of Dental Materials·L Le GuéhennecY Amouriq
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Mar 21, 2007·Journal of Cellular and Molecular Medicine·Denitsa DochevaMatthias Schieker
May 2, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sirong YuYingjie Yu
Jul 11, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Daqing WeiYaming Wang
Mar 4, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Lin FengLei Jiang
Jun 12, 2008·Journal of Biomedical Materials Research. Part a·Zhongwei ZhaoShimei Wen
Jul 12, 2008·Biomaterials·Gustavo MendonçaLyndon F Cooper
Dec 17, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Cheol-Min HanSuk-Ku Han
Jan 31, 2009·Proceedings of the National Academy of Sciences of the United States of America·Seunghan OhSungho Jin
May 7, 2009·Nanotechnology·Timothy RuckhKetul C Popat
Jul 3, 2009·Cell Stem Cell·Farshid GuilakChristopher S Chen
Oct 6, 2009·Journal of Biomechanics·Gwendolen C Reilly, Adam J Engler
Jul 23, 2011·Nature Chemistry·Morgan D MagerMolly M Stevens
May 9, 2014·Biomaterials·Saber Amin YavariAmir Abbas Zadpoor
Jun 9, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Laís T DuartePedro A P Nascente
Jul 22, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Wenjie ZhangXinquan Jiang
Oct 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lijing HaoYingjun Wang
Jun 6, 2015·Materials Science & Engineering. C, Materials for Biological Applications·A R RibeiroJ M Granjeiro
Jul 22, 2015·Colloids and Surfaces. B, Biointerfaces·Qianli HuangQingling Feng

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Citations

Aug 31, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Deliang ZengXinquan Jiang
Oct 5, 2019·Journal of Materials Science. Materials in Medicine·Rong-Jian LuHong-Chen Liu
Oct 17, 2017·Frontiers in Immunology·Xiangwei YuanXianlong Zhang
Jan 10, 2019·Nanomaterials·Nadine ZieglerAlfred Ludwig
Mar 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhang YuanKaiyong Cai
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Peng WangJi-Hua Li
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Bing RenYong Huang
Apr 9, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Maryam MolaeiArash Fattah-Alhosseini
May 1, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fengxiong LuoXingdong Zhang
Oct 3, 2018·ACS Applied Materials & Interfaces·Yang ZhangJeroen J J P van den Beucken
Dec 4, 2019·ACS Applied Materials & Interfaces·Lin XuJianning Ding

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