Enhanced osteointegration on tantalum-implanted polyetheretherketone surface with bone-like elastic modulus

Biomaterials
Tao LuPaul K Chu

Abstract

Polyetheretherketone (PEEK) possesses a similar elastic modulus as bones but yet suffers from bio-inertness and poor osteogenesis. In this work, tantalum ions are implanted energetically into PEEK by plasma immersion ion implantation (PIII) to form Ta2O5 nanoparticles in the near surface. Nanoindentation reveals that the surface elastic modulus of the Ta ion implanted PEEK is closer to that of human cortical bones. In vitro cell adhesion, alkaline phosphatase activity, collagen secretion, extracellular matrix mineralization, and real-time PCR analyses disclose enhanced adhesion, proliferation, and osteogenic differentiation of rat bone mesenchymal stem cells (bMSCs) on the Ta-PIII modified PEEK. In vivo evaluation of the cortico-cancellous rat femur model by means of micro-CT, sequential fluorescent labeling, and histological analysis after 8 weeks confirms significantly improved osteointegration. The bone-like elastic modulus and modified surface topography of the Ta-PIII modified PEEK synergistically induce osteogenic differentiation of bMSCs and the surface-modified materials have large potential in dental and orthopedic implants.

References

Jul 29, 1998·Medical Engineering & Physics·J Y RhoP Zioupos
Apr 18, 2003·Biomaterials·Tadashi KokuboMasakazu Kawashita
May 22, 2003·Journal of Biomechanics·Elise F MorganTony M Keaveny
Jun 15, 2004·Biomaterials·Yoshimitsu Okazaki, Emiko Gotoh
Aug 24, 2005·Biomaterials·Jeffrey M TothA Simon Turner
Jan 21, 2006·Biomaterials·Garrett RyanDimitrios Panagiotis Apatsidis
Jun 2, 2006·Biomaterials·Brett Russell LevineJoshua J Jacobs
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Jul 20, 2007·Journal of Biomedical Materials Research. Part a·Katie J WelldonDavid M Findlay
Aug 10, 2007·Biomaterials·Steven M Kurtz, John N Devine
Aug 1, 2008·Journal of the Royal Society, Interface·M NavarroJ A Planell
Jun 16, 2009·Nature Materials·Andre E NelMike Thompson
Jun 27, 2009·Science·Dennis E DischerPeter W Zandstra
Jul 7, 2012·Acta Biomaterialia·Mitsuo NiinomiJunko Hieda
Mar 19, 2014·Colloids and Surfaces. B, Biointerfaces·Heying WangXuanyong Liu
May 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Huifeng WangJianming Ruan

❮ Previous
Next ❯

Citations

Jan 23, 2016·ACS Applied Materials & Interfaces·Ying ZhaoKelvin W K Yeung
Mar 10, 2016·Colloids and Surfaces. B, Biointerfaces·Tao LuXuanyong Liu
May 31, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohammad VaeziShoufeng Yang
Oct 23, 2016·Dental Materials : Official Publication of the Academy of Dental Materials·Kang GanChenchen Liu
Oct 27, 2016·Journal of Biomedical Materials Research. Part a·Yu ZhuHongchang Lai
Jan 31, 2017·Nanomedicine : Nanotechnology, Biology, and Medicine·Xilin LiuXiaojian Ye
Jan 14, 2017·Scientific Reports·W T HuoY S Zhang
Aug 5, 2017·Materials·Karthika PrasadKateryna Bazaka
May 17, 2018·Journal of Biomaterials Science. Polymer Edition·Chunyan WangZhi-Gang Chen
Nov 7, 2017·Journal of Biomaterials Applications·Kai TangXiaodong Guo
Dec 28, 2018·Clinical Implant Dentistry and Related Research·Sunil Mishra, Ramesh Chowdhary
May 28, 2019·Journal of Medicine and Life·Lakshmana BathalaSirisha Gedela
Sep 5, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qinwen ChengXingdong Zhang
Feb 14, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Fatih Erdem Baştan
Jan 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jian LiXuanyong Liu
Sep 6, 2019·Annals of Biomedical Engineering·Abinash Padhi, Amrinder S Nain
Jun 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mengfei YuHuiming Wang
Sep 15, 2017·Tissue Engineering. Part B, Reviews·Longwei LvYongsheng Zhou
Aug 11, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Niyou WangA Senthil Kumar
Aug 28, 2020·Journal of Biomaterials Science. Polymer Edition·Yue YuYi Deng
Oct 12, 2017·Journal of Dental Research·H ShaoZ Gou
Sep 2, 2020·The Journal of the American Academy of Orthopaedic Surgeons·Daniel PossleyJad G Khalil
Nov 27, 2020·International Journal of Nanomedicine·Haiyan WangJing Guo
Jan 30, 2021·Frontiers in Bioengineering and Biotechnology·Xinming GuYanmin Zhou
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Shuyi WuLili Yao
Feb 18, 2021·Trends in Biotechnology·Nathaniel F C HenningMonica M Laronda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.