Enhanced ototoxicity of gentamicin and salicylate caused by Mg deficiency and Zn deficiency

Biological Trace Element Research
T GüntherH Ising

Abstract

In rats, Mg deficiency caused a moderate hearing loss, measured by means of evoked potentials at 10 and 20 kHz, which was repaired after refeeding a normal diet. Application of 700 mg/kg salicylic acid or injection of 5 x 100 mg/kg gentamicin also caused a reversible hearing loss in normally fed rats. Treatment of Zn-deficient rats with salicylic acid produced a stronger although reversible hearing loss than in normally fed salicylate-treated rats. Treatment of Mg-deficient rats with gentamicin induced a strong hearing loss that was nearly complete and irreversible in 9 of 25 rats.

References

Jan 1, 1986·Hearing Research·J Schacht
Jul 1, 1986·Prostaglandins, Leukotrienes, and Medicine·S NigamT Günther
Feb 1, 1987·The Proceedings of the Nutrition Society·T F SlaterW Xin
Oct 1, 1986·Chemico-biological Interactions·M E Kyle, J J Kocsis
Dec 1, 1987·Proceedings of the Society for Experimental Biology and Medicine·L S RamsammyG J Kaloyanides
Jan 1, 1986·Acta Oto-laryngologica. Supplementum·R Pujol
Jan 1, 1987·Contributions to Nephrology·D KleinknechtB Goldfarb
Feb 1, 1987·The Proceedings of the Nutrition Society·B Halliwell
Feb 1, 1987·The Proceedings of the Nutrition Society·R L Willson
Jun 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·J P Burke, M R Fenton
Nov 1, 1985·Toxicology and Applied Pharmacology·M E Kyle, J J Kocsis
Jul 1, 1983·The Journal of the Acoustical Society of America·Z JoachimsM Handrock
Mar 1, 1981·International Ophthalmology·J T FlynnM Barricks
Sep 9, 1965·The New England Journal of Medicine·E N MYERSG FOSTIROPOLOUS

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Citations

Jul 6, 2000·Progress in Neurobiology·Y Cazals
Sep 23, 2003·Critical Care Medicine·Robin J Hamill-Ruth, Roger A Ruth
Oct 12, 2010·The Laryngoscope·Chao-Hui YangChung-Feng Hwang
Sep 27, 2005·American Journal of Audiology·Susan G StantonSarah C Couch
Jan 15, 1999·Audiology : Official Organ of the International Society of Audiology·R J Hamill-RuthB Turrentine
Oct 16, 2003·Journal of Basic and Clinical Physiology and Pharmacology·Joseph AttiasHartmut Ising
Jan 3, 2012·Neuroreport·Woo Seok KangJong Woo Chung
Dec 1, 1988·Biological Trace Element Research·T GüntherR Graf

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