Enhanced Performance of a Molecular Photoacoustic Imaging Agent by Encapsulation in Mesoporous Silicon Nanoparticles

Advanced Materials
Jinyoung KangMichael J Sailor

Abstract

Photoacoustic (PA) imaging allows visualization of the physiology and pathology of tissues with good spatial resolution and relatively deep tissue penetration. The method converts near-infrared (NIR) laser excitation into thermal expansion, generating pressure transients that are detected with an acoustic transducer. Here, we find that the response of the PA contrast agent indocyanine green (ICG) can be enhanced 17-fold when it is sealed within a rigid nanoparticle. ICG encapsulated in particles composed of porous silicon (pSiNP), porous silica, or calcium silicate all show greater PA contrast relative to equivalent quantities of free ICG, with the pSiNPs showing the strongest enhancement. A liposomal formulation of ICG performs similar to free ICG, suggesting that a rigid host nanostructure is necessary to enhance ICG performance. The improved response of the nanoparticle formulations is attributed to the low thermal conductivity of the porous inorganic hosts and their ability to protect the ICG payload from photolytic and/or thermal degradation. The translational potential of ICG-loaded pSiNPs as photoacoustic probes is demonstrated via imaging of a whole mouse brain.

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Citations

Dec 18, 2018·Advanced Materials·Qinrui FuXiaoyuan Chen
Dec 19, 2018·Materials·Seo Hyeon LeeDokyoung Kim
Jun 6, 2020·Biomedical Optics Express·Parastoo FarniaJesse V Jokerst
Nov 5, 2019·Journal of Imaging·Van Phuc Nguyen, Yannis M Paulus
Jul 12, 2019·Advanced Drug Delivery Reviews·Colman MooreJesse V Jokerst
Feb 18, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Daniel RazanskyRuiqing Ni
Apr 27, 2021·Nano Today·Jinping WangHongjun Wang
May 12, 2021·Journal of the American Chemical Society·Mengliang ZhuJun-Long Zhang
Jul 23, 2021·ACS Biomaterials Science & Engineering·Ruoyu ChengHélder A Santos
Mar 11, 2019·ACS Biomaterials Science & Engineering·Yumin ZhangJianfeng Liu
Jan 11, 2020·ACS Applied Materials & Interfaces·Wujun XuVesa-Pekka Lehto
Oct 6, 2021·Chemical Reviews·Linlin DuanDongyuan Zhao

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