Mar 11, 2015

Enhanced perfusion during advanced life support improves survival with favorable neurologic function in a porcine model of refractory cardiac arrest

Critical Care Medicine
Guillaume DebatyKeith G Lurie

Abstract

To improve the likelihood for survival with favorable neurologic function after cardiac arrest, we assessed a new advanced life support approach using active compression-decompression cardiopulmonary resuscitation plus an intrathoracic pressure regulator. Prospective animal investigation. Animal laboratory. Female farm pigs (n = 25) (39 ± 3 kg). Protocol A: After 12 minutes of untreated ventricular fibrillation, 18 pigs were randomized to group A-3 minutes of basic life support with standard cardiopulmonary resuscitation, defibrillation, and if needed 2 minutes of advanced life support with standard cardiopulmonary resuscitation; group B-3 minutes of basic life support with standard cardiopulmonary resuscitation, defibrillation, and if needed 2 minutes of advanced life support with active compression-decompression plus intrathoracic pressure regulator; and group C-3 minutes of basic life support with active compression-decompression cardiopulmonary resuscitation plus an impedance threshold device, defibrillation, and if needed 2 minutes of advanced life support with active compression-decompression plus intrathoracic pressure regulator. Advanced life support always included IV epinephrine (0.05 μg/kg). The primary endpoint was ...Continue Reading

Mentioned in this Paper

Coronary Circulation
Ventricular Fibrillation
Cerebral Blood Flow Imaging
PIGS
Electric Impedance
Myocardial Disorder
Blood Pressure Regulation
Brain
Myocardium
Basic Cardiac Life Support

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