Enhanced perfusion during advanced life support improves survival with favorable neurologic function in a porcine model of refractory cardiac arrest

Critical Care Medicine
Guillaume DebatyK G Lurie

Abstract

To improve the likelihood for survival with favorable neurologic function after cardiac arrest, we assessed a new advanced life support approach using active compression-decompression cardiopulmonary resuscitation plus an intrathoracic pressure regulator. Prospective animal investigation. Animal laboratory. Female farm pigs (n = 25) (39 ± 3 kg). Protocol A: After 12 minutes of untreated ventricular fibrillation, 18 pigs were randomized to group A-3 minutes of basic life support with standard cardiopulmonary resuscitation, defibrillation, and if needed 2 minutes of advanced life support with standard cardiopulmonary resuscitation; group B-3 minutes of basic life support with standard cardiopulmonary resuscitation, defibrillation, and if needed 2 minutes of advanced life support with active compression-decompression plus intrathoracic pressure regulator; and group C-3 minutes of basic life support with active compression-decompression cardiopulmonary resuscitation plus an impedance threshold device, defibrillation, and if needed 2 minutes of advanced life support with active compression-decompression plus intrathoracic pressure regulator. Advanced life support always included IV epinephrine (0.05 μg/kg). The primary endpoint was ...Continue Reading

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Citations

Nov 13, 2015·Anesthesia and Analgesia·Keith G LurieMichael Sweeney
Mar 28, 2017·Current Opinion in Critical Care·Johanna C MooreDemetris Yannopoulos
Feb 21, 2021·Annals of the New York Academy of Sciences·Tom P AufderheideDemetris Yannopoulos

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