Enhanced phagocytosis and bactericidal activity of hepatic reticuloendothelial system during endotoxin tolerance.

Infection and Immunity
G RuggieroD Galante

Abstract

The effects of tolerance to Escherichia coli endotoxin on the phagocytic and bactericidal activity of the hepatic reticuloendothelial system against viable E. coli were examined using ex vivo perfused rat livers. Livers were isolated from control and endotoxin-tolerant rats and perfused with a medium containing 5% homologous serum from either control or tolerant rats. After the addition of the E. coli (2 x 10(7) cells per ml) to the perfusate, the hepatic clearance of the bacteria was followed for 30 min. The highest activation of the hepatic reticuloendothelial system was observed when serum from tolerant animals was added to the perfusate. Under these conditions phagocytosis was 47% (12% in controls), and 37 to 38% of the bacteria were killed (5% in controls). This activation was less when livers obtained from tolerant rats were perfused with serum from controls or with saline only. The data suggests that, during endotoxin tolerance, humoral factors play an important role in the activation of the hepatic reticulendothelial system, although a direct stimulation of Kupffer cells also occurs. The enhancement of phagocytosis by tolerant serum did not require the presence of homologous antibodies and involved the activation of the...Continue Reading

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Jan 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P S Richards, T M Saba
May 1, 1986·The Japanese Journal of Surgery·Y YamaguchiM Akagi
Aug 4, 2006·Journal of Leukocyte Biology·Julliette M BuckleyH Paul Redmond
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