Abstract
Photodynamic therapy (PDT) is a promising alternative to conventional cancer treatment methods. Nonetheless, improvement of in vivo light penetration and cancer cell-targeting efficiency remain major challenges in clinical photodynamic therapy. This study aimed to develop multifunctional magnetic nanoparticles conjugated with a photosensitizer (PS) and cancer-targeting molecules via a simple surface modification process for PDT. To selectively target cancer cells and PDT functionality, core magnetic (Fe₃O₄) nanoparticles were covalently bound with chlorin e6 (Ce6) as a PS and folic acid (FA). When irradiated with a 660-nm long-wavelength light source, the Fe₃O₄-Ce6-FA nanoparticles with good biocompatibility exerted marked anticancer effects via apoptosis, as confirmed by analyzing the translocation of the plasma membrane, nuclear fragmentation, activities of caspase-3/7 in prostate (PC-3) and breast (MCF-7) cancer cells. Ce6, used herein as a PS, is thus more useful for PDT because of its ability to produce a high singlet oxygen quantum yield, which is owed to deep penetration by virtue of its long-wavelength absorption band; however, further in vivo studies are required to verify its biological effects for clinical applications.
References
Jun 1, 1993·Photochemistry and Photobiology·A M RichterJ G Levy
May 2, 2003·Nature Reviews. Cancer·Dennis E J G J DolmansRakesh K Jain
Sep 1, 2005·Journal of the American Chemical Society·Takatoshi YogoTetsuo Nagano
Aug 28, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Sean MathaiKenneth P Ghiggino
Sep 23, 2008·Trends in Biotechnology·Denise BechetMuriel Barberi-Heyob
Oct 7, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Liane M RossiMaurício S Baptista
Jan 29, 2010·Chemical Reviews·Jonathan F LovellGang Zheng
Apr 1, 2010·Chemical Reviews·Jonathan P CelliTayyaba Hasan
May 28, 2011·CA: a Cancer Journal for Clinicians·Patrizia AgostinisJakub Golab
Oct 21, 2011·Angewandte Chemie·Yusuf CakmakEngin U Akkaya
Dec 12, 2012·Journal of Fluorescence·Shubhajit PaulLai Wah Chan
Mar 19, 2013·Journal of the American Chemical Society·Yi WangRongqin Huang
Jul 5, 2013·ACS Nano·Chao WangZhuang Liu
Aug 27, 2013·Advanced Drug Delivery Reviews·Niravkumar R PatelVladimir P Torchilin
May 9, 2014·ACS Nano·Zipeng ZhenJin Xie
Aug 12, 2014·Nature Communications·Jiechao GeXiaodong Han
Sep 2, 2014·Biomaterials·Zhenzhen WangXiaogang Qu
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Dec 1, 2014·Biomaterials·Gan TianYuliang Zhao
Dec 6, 2014·Advanced Functional Materials·Yucai WangYounan Xia
Apr 16, 2015·Angewandte Chemie·Xuesong Ding, Bao-Hang Han
Sep 10, 2015·Journal of Biomedical Nanotechnology·Bong Joo ParkEun Ha Choi
Oct 16, 2015·Chemical Reviews·Mahmoud ElsabahyKaren L Wooley
Feb 11, 2016·International Journal of Molecular Sciences·Cheng-Yi TangYong-Hua Yang
Sep 9, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kyong-Hoon ChoiBong Joo Park
May 23, 2017·Theranostics·Juan MouHangrong Chen
Jun 8, 2017·Cancers·Ting LuoQing-Bin Lu
Jun 13, 2017·Nanomaterials·Kyong-Hoon ChoiBong Joo Park
Citations
Dec 7, 2019·Biomaterials Science·Liming DengZhigang Wang
Mar 4, 2020·Cancers·Ki Chang NamBong Joo Park
Oct 24, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Novi IrmaniaJia-Yaw Chang
Aug 11, 2020·Drug Delivery·Rahime Eshaghi MalekshahAli Khaleghian
Nov 19, 2019·Frontiers in Chemistry·Claudia FerroniGreta Varchi
Aug 18, 2020·Nanotechnology, Science and Applications·Mojgan SheikhpourZahra Taherian
Jan 1, 2020·Nanomaterials·Roxana Cristina PopescuBogdan Stefan Vasile
May 6, 2020·International Journal of Nanomedicine·Rahime Eshaghi MalekshahAli Khaleghian
May 8, 2020·Photodiagnosis and Photodynamic Therapy·Agnieszka SzurkoAlicja Ratuszna
Oct 3, 2020·Acta Biomaterialia·Bin LiuDaxiang Cui
Jan 27, 2021·Photodiagnosis and Photodynamic Therapy·Maiara L CastilhoL Raniero
Oct 23, 2020·Nanomaterials·Liang HongParas N Prasad
Mar 7, 2021·Pharmaceutics·Hanieh MontaseriHeidi Abrahamse
Jul 14, 2021·Expert Opinion on Drug Delivery·Lin HuangYanyu Xiao