Enhanced photodynamic therapy efficacy of methylene blue-loaded calcium phosphate nanoparticles

Journal of Photochemistry and Photobiology. B, Biology
Da-Young Seong, Young-Jin Kim

Abstract

Although methylene blue (MB) is the most inexpensive photosensitizer with promising applications in the photodynamic therapy (PDT) for its high quantum yield of singlet oxygen generation, the clinical use of MB has been limited by its rapid enzymatic reduction in the biological environment. To enhance PDT efficacy of MB by preventing the enzymatic reduction, we have developed a new mineralization method to produce highly biocompatible MB-loaded calcium phosphate (CaP-MB) nanoparticles in the presence of polymer templates. The resulting CaP-MB nanoparticles exhibited spherical shape with a size of under 50 nm. Fourier transform infrared (FT-IR) and zeta-potential analyses confirmed the insertion of MB into the CaP-MB nanoparticles. The encapsulation of MB in CaP nanoparticles could effectively protect MB from the enzymatic reduction. In addition, the CaP-MB nanoparticles exhibited a good biocompatibility in the dark condition and significantly enhanced PDT efficacy due to apoptotic cell death against human breast cancer cells as compared with free MB, implying that CaP-MB nanoparticle system might be potentially applicable in PDT.

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Citations

Aug 16, 2016·Photodiagnosis and Photodynamic Therapy·Arash AziziShirin Lawaf
Mar 28, 2017·Photodiagnosis and Photodynamic Therapy·Sávio M L GontijoPatrícia V Araújo
Oct 11, 2016·Chemical Society Reviews·Wenpei FanXiaoyuan Chen
Nov 7, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Krzysztof SztanderaBarbara Klajnert-Maculewicz
Dec 21, 2017·Chemical Society Reviews·Chao QiPeng Huang
Jan 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ya WenYongyong Li
Mar 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Monika DabrzalskaBarbara Klajnert-Maculewicz
Jul 26, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Gayong ShimYu-Kyoung Oh
Jul 19, 2018·International Journal of Pharmaceutics·Maria Teresa Junqueira GarciaLuciana Biagini Lopes

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