PMID: 11339428May 8, 2001Paper

Enhanced polyadenosine diphosphate-ribosylation in cirrhotic liver and carcinoma tissues in patients with hepatocellular carcinoma

Journal of Gastroenterology and Hepatology
M ShiobaraM Noda

Abstract

The aim of this study is to assess the poly ADP-ribosylation activity in human hepatocellular carcinoma (HCC) and in liver cirrhosis (LC) as compared to the activity in normal livers (NL). Hepatocellular carcinoma and LC tissues were sampled from 19 patients with HCC. Normal liver tissue was obtained from 19 patients with metastatic liver cancer. Poly ADP-ribosylation activity of these tissues was measured by using [32P]-adenylate nicotinamide adenine dinucleotide (NAD)-incorporation into the 116-kDa protein. Nicotinamide adenine dinucleotide glycohydrolase activity of these tissues was determined with thin layer chromatography. The immunohistochemical expression of Ki-67 was also assessed as a parameter of cell proliferative activity. The poly ADP-ribosylation of the 116 kDa protein was significantly increased in patients with HCC and LC as compared with NL (P<0.0001, P<0.05, respectively) and was inhibited by poly (ADP-ribose) polymerase inhibitors in a dose-dependent manner. There was no significant difference in NAD glycohydrolase activity among the three groups. A significant correlation was found between the Ki-67 positive cell rate and the relative radioactivity of poly ADP-ribosylation in HCC patients (r=0.794, P<0.0001...Continue Reading

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Mar 1, 2011·Alice Chen, M.D., Alice Chen, M.D.

References

Jan 1, 1976·Reviews of Physiology, Biochemistry and Pharmacology·H Hilz, P Stone
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Nov 1, 1990·Biological Reviews of the Cambridge Philosophical Society·T Alderson
Jan 1, 1989·Mutation Research·B Chatterjee, P K Ghosh
Jan 1, 1985·Annual Review of Biochemistry·K Ueda, O Hayaishi
Feb 7, 1980·Nature·B W DurkaczS Shall
Sep 11, 1993·Lancet·I R Judson, M D Threadgill
Nov 15, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C M SchmidtJ V Sitzmann

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Citations

Jun 16, 2009·Cancer Chemotherapy and Pharmacology·Jodi A MuscalJack M Su
Sep 25, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Angelica Fasolo, Cristiana Sessa
Apr 13, 2010·Pathology Oncology Research : POR·Nilufer Jasmine Selimah FauzeeYa-lan Wang
Nov 25, 2004·Progress in Biophysics and Molecular Biology·Paul A NguewaJosé M Pérez
Oct 30, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B Pothuri
Apr 21, 2010·The Cancer Journal·Elaina M GartnerPatricia M Lorusso
Oct 8, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Davide MelisiPaul J Chiao
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shivaani KummarJames H Doroshow
Aug 21, 2013·Clinics and Research in Hepatology and Gastroenterology·Clément GuillotIsabelle Chemin
Jan 24, 2014·Clinical Pharmacokinetics·Ahmed Hamed SalemNael M Mostafa
Oct 10, 2008·The British Journal of Radiology·C Jones, E R Plummer
Aug 30, 2013·Nihon saikingaku zasshi. Japanese journal of bacteriology·Masatoshi Noda
Mar 29, 2011·Leukemia & Lymphoma·Panagiota EconomopoulouTheofanis Economopoulos
Apr 2, 2013·International Journal of Radiation Oncology, Biology, Physics·Joseph W SheltonHui-Kuo G Shu
Oct 4, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Partha MukhopadhyayPal Pacher
Sep 21, 2010·International Journal of Cancer. Journal International Du Cancer·Aswin Mangerich, Alexander Bürkle
Jan 10, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jun-Xiang ZhangRakesh Kumar
Jun 18, 2009·Pediatric Blood & Cancer·Valerie N BartonNicholas K Foreman
Apr 29, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lucio TentoriGrazia Graziani
Jun 20, 2016·International Immunopharmacology·Shuai WangYi-Tao Ding
May 10, 2005·Expert Review of Anticancer Therapy·Yan Luo, Joel D Leverson
Mar 21, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Reshma JagsiUNKNOWN Translational Breast Cancer Research Consortium
Feb 18, 2017·The Journal of Pharmacology and Experimental Therapeutics·Enrique ChávezVictoria Chagoya de Sánchez
Apr 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Idil Cetin, Mehmet Topcul
Mar 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kapila Ratnam, Jennifer A Low
May 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cherrie K DonawhoDavid J Frost
Mar 21, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jacob D SoumeraiJohn F Gerecitano
Jun 21, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jing LiPatricia LoRusso
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·E Ruth PlummerNicola J Curtin

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