Enhanced production of glomerular extracellular matrix in a new mouse strain of high serum IgA ddY mice

Kidney International
E MusoS Sasayama

Abstract

To investigate the relationship between high serum levels of IgA and glomerular lesions, selective mating was performed in high serum IgA ddY mice, a murine model of spontaneously developing mesangioproliferative glomerulonephritis mimicking human IgA nephropathy. The selection and mating of high IgA ddY mice were accomplished when the mice were three to four months old. In the 12th generation of high IgA ddY (HIGA) mice, significantly higher levels of serum IgA from 10 age weeks to 60 weeks (P < 0.0002 to 0.0001) were observed in comparison with BALB/c mice. Relatively high proteinuria was observed at 40 weeks of age, although hematuria was consistently negative. Microscopic observations of renal tissue disclosed a marked glomerular mesangial matrix increase and a reduction of cell proliferation with age by both semiquantitative and morphometric analyses with moderate tubulointerstitial damage. These mesangial matrices were stained markedly by antisera for collagen type IV and by fibronectin, but not by collagen type I. Localization of TGF-beta protein was also detected in the mesangium of the HIGA mice. The positive mesangial IgA deposition was maintained consistently by this mating procedure and became more marked with age. ...Continue Reading

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Citations

Jul 21, 1999·Kidney International. Supplement·F NogakiS Sasayama
Jul 20, 1999·Current Opinion in Rheumatology·V Montenegro, R C Monteiro
Aug 14, 2009·Clinical and Experimental Pharmacology & Physiology·Naro OhashiHiroyuki Kobori
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