Enhanced protection of cyclophosphamide-treated mice against infection with Pseudomonas aeruginosa after treatment with Z-100, a polysaccharide-rich extract from Mycobacterium tuberculosis Aoyama B

Immunopharmacology and Immunotoxicology
I KawamuraK Nomoto

Abstract

We investigated the effect of Z-100, a polysaccharide-rich extract from Mycobacterium tuberculosis strain Aoyama B, on the protection of immunocompromised mice against infection with Pseudomonas aeruginosa. Mice were given cyclophosphamide and then treated with varying doses of Z-100 for 5 days or left untreated. One day after the completion of the treatment, they were challenged with P. aeruginosa and the mortality was scored. A significantly enhanced protection was observed in the treated group and bacterial number in organs was significantly lower compared with non-treated group. Though the activity of phagocytes did not appear to be activated since there was no difference in chemiluminescence response of peritoneal phagocytes between control and Z-100-treated groups, an enhanced accumulation of phagocytes was observed after bacterial challenge in Z-100-treated group. It was suggested that Z-100 is effective in the restoration of impaired resistance of immuno-compromised mice to bacterial infection possibly through a stimulation of phagocyte accumulation into the site of infection.

References

May 1, 1978·Journal of General Microbiology·M MitsuyamaS Shimotori
Aug 1, 1981·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·H KobatakeH Kushida
Jan 1, 1982·Current Medical Research and Opinion·G N VolansT Frost

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Citations

Nov 1, 1994·The Journal of International Medical Research·C K WongY M Choy

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