Enhanced pulmonary inflammation following experimental intracerebral hemorrhage

Experimental Neurology
Shan WuJun Ren

Abstract

The association between brain damage and respiratory dysfunction has been recognized although mechanistic link between the two is still poorly defined. Intracerebral hemorrhage is accompanied by brain injury, stroke, and parenchymal hematoma formation with surrounding inflammation. Increase intracranial pressure as a result of intracerebral hemorrhage may promote localized activation of cytokines and coagulation system including tissue factor release. However, whether intracerebral hemorrhage triggers inflammation in noncerebral organs has not been elucidated. The aim of the present study was to examine the impact of intracerebral hemorrhage on lung inflammatory response. Intracerebral hemorrhage was induced by stereotaxic intrastriatal administration of bacterial collagenase. Expression of intracellular adhesion molecule-1 (ICAM-1), IKB-alpha, tissue factor, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) was evaluated by Western blot analysis. Our results revealed that intracerebral hemorrhage upregulated expression of ICAM-1 and tissue factor in both brain and lung, whereas it enhanced TNF-alpha and IL-1beta mainly in brain within 6 and 24 h of the brain injury. Levels of IKB-alpha remained unchange...Continue Reading

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Citations

Jun 22, 2007·Critical Care : the Official Journal of the Critical Care Forum·Romina GonzalvoJosefina López-Aguilar
Apr 28, 2009·Brain, Behavior, and Immunity·Anna CataniaStefano Gatti
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Jan 19, 2017·Molecular Medicine Reports·Lian-Jie LvZhi-Ming Zhang
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Jul 14, 2020·Anaesthesia Critical Care & Pain Medicine·Ségolène MrozekThomas Geeraerts
Oct 15, 2021·Critical Care : the Official Journal of the Critical Care Forum·Mairi Ziaka, Aristomenis Exadaktylos

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