PMID: 9542593May 30, 1998Paper

Enhanced reactivity of Alz-50 antibody in brains of sudden infant death syndrome victims versus brains with lethal hypoxic/ischemic injury. Diagnostic significance after application of the ImmunoMax technique on routine paraffin material

Acta Neuropathologica
M OehmichenC Meissner

Abstract

Alz-50 antibody is immunoreactive with brain tissue of subjects with Alzheimer's disease and can also be demonstrated by immunocytochemistry in neurons of vibratome-prepared brain tissue of victims of sudden infant death syndrome (SIDS). The application of a slightly modified ImmunoMax method enabled us to demonstrate Alz-50 immunoreactivity in paraffin-embedded material. The Alz-50 epitope was detected in the hippocampus region and in nuclei of the medulla oblongata at the level of the inferior olivary protuberance in three diagnostic groups: victims of SIDS (n = 10), infants dying of subacute hypoxia/ischemia with subsequent (re-)perfusion (n = 9), and infants dying of acute ischemia without (re-) perfusion (n = 7). Quantitative evaluation of the hippocampal cortex and the nucleus olivaris inferior disclosed a significantly (P < 0.05) higher percentage of Alz-50-reactive neurons in SIDS cases than in the control groups (hippocampal cortex and the nucleus olivaris; SIDS victims: median = 100%; subacute hypoxia/ischemia: median = 33.6-81%; acute ischemia: median = 89.2-99%). Semiquantitative analysis revealed an equally pronounced preponderance of Alz-50-reactive neurons in SIDS victims versus the control groups. This greater e...Continue Reading

Citations

Mar 17, 2007·Acta Neuropathologica·R MachaalaniK A Waters
Nov 15, 2008·Acta Neuropathologica·Manfred OehmichenChristoph Meissner
Oct 12, 2014·Paediatric Respiratory Reviews·Rita Machaalani, Karen A Waters
Oct 25, 2011·Respiratory Physiology & Neurobiology·Samantha TangKaren A Waters
Oct 18, 2013·Neuropathology and Applied Neurobiology·Simon M L PaineNeil J Sebire
Sep 15, 2004·Forensic Science International : Synergy·K-S Saternus
Jan 24, 2007·Journal of Forensic and Legal Medicine·K-S SaternusG Kernbach-Wighton
Jun 25, 2020·Apoptosis : an International Journal on Programmed Cell Death·L L M LuijerinkR Machaalani

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