Enhanced recovery from thrombocytopenia and neutropenia in mice constitutively expressing a placental hematopoietic cytokine

Endocrinology
Beiyan ZhouDaniel I H Linzer

Abstract

Expression of the placental hormone, prolactin-like protein E (PLP-E), a potent cytokine that acts on multiple myeloid lineages, is normally restricted to pregnancy and certain hematopoietic disease states. We hypothesized that the restricted pattern of PLP-E expression is necessary to avoid hyperstimulation of myelopoiesis. To test this idea, we have produced PLP-E transgenic mice and analyzed their steady-state blood cell levels. We find that blood cell levels remain in the normal range, and thus the constitutive expression of a cytokine of pregnancy fails to overcome the tight control of hematopoietic set points for blood cell levels. In contrast, an effect of constitutive PLP-E expression is detected during the recovery from low blood platelet levels (acute thrombocytopenia) and from low granulocyte levels (acute neutropenia) but not from anemia. Mice producing high circulating concentrations of PLP-E recover more rapidly from both thrombocytopenia and neutropenia, as seen both by an earlier increase of progenitor numbers in the bone marrow and the earlier return to normal circulating blood cell levels.

References

Apr 1, 1991·Journal of Cellular Physiology·P E StenbergL Corash
Mar 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·C J KovacsR M Johnke
Jun 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K Tsuji-TakayamaM Kurimoto
Jul 20, 1999·The Journal of Biological Chemistry·J Lin, D I Linzer
Jun 1, 2002·Molecular Endocrinology·Sumit BhattacharyyaDaniel I H Linzer
Dec 19, 2002·Endocrinology·Dustin O WiemersMichael J Soares

❮ Previous
Next ❯

Citations

Feb 28, 2007·Trends in Endocrinology and Metabolism : TEM·Michael J SoaresS M Khorshed Alam
Mar 18, 2016·Biology of Reproduction·Pengli BuMichael Soares
Feb 16, 2006·Reproduction, Fertility, and Development·James C Cross
Feb 8, 2008·Reproduction, Fertility, and Development·Juan J BustamanteMichael J Soares
Sep 4, 2018·Frontiers in Physiology·Tina NapsoAmanda N Sferruzzi-Perri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.