Enhanced renal parenchymal cryoablation with novel 17-gauge cryoprobes

Urology
Caroline D AmesJaime Landman

Abstract

To evaluate novel, 17-gauge cryoprobes with a modified heat exchange mechanism to evaluate the area of ablation that could be achieved with 17-gauge (1.47-mm) cryoprobes. Eleven pigs were divided into four groups. Each animal underwent laparoscopic creation of three cryolesions with an ellipical iceball-generating 17-gauge cryoprobe (group 1), one that generates a teardrop-shaped iceball (group 2), a template of three standard 17-gauge cryoprobes (group 3), or a single, standard, large-caliber (3.4-mm) cryoprobe (group 4). Each cryolesion was created with a standard double-freeze cycle. Intraoperative ultrasonography was used to measure the maximal iceball dimensions, and the renal temperatures were measured with a thermocouple. The animals were killed after 14 days. The gross lesion size and histopathologic area of necrosis were documented. The mean temperature for the surrounding renal parenchyma was not significantly different among the groups. No statistically significant difference was noted in the size of the gross or histopathologic lesions created among the four groups. The gross lesion size correlated statistically significantly with the histologic area of necrosis (P <0.01). Despite the diminutive size of the 17-gauge...Continue Reading

References

Jan 1, 1996·The Journal of Urology·M G DelworthA C von Eschenbach
Oct 8, 1998·Urology·I S GillC M O'Malley
Jul 31, 2003·BJU International·W B Shingleton, P E Sewell

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Citations

May 25, 2005·Journal of Endourology·John L GorePeter Schulam
Jul 24, 2010·Journal of Endourology·Preston C SprenkleJaime Landman
Dec 24, 2011·Urology·Jennifer L YoungRalph V Clayman
Jun 21, 2011·The Journal of Urology·Brunolf W LagerveldJos A E Spaan
Jul 14, 2010·Journal of Vascular and Interventional Radiology : JVIR·Grant D SchmitJ William Charboneau
Mar 7, 2006·Journal of Vascular and Interventional Radiology : JVIR·Andrew Hines-PeraltaS Nahum Goldberg
May 20, 2008·BJU International·Gregory HrubyJaime Landman

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