Enhanced responses of the chorda tympani nerve to nonsugar sweeteners in the diabetic db/db mouse

The American Journal of Physiology
Y NinomiyaH Katsukawa

Abstract

Genetically diabetic db/db mice show greater neural and behavioral responses to sugars than lean control mice. The present study examined chorda tympani responses of db/db mice to nonsugar sweeteners and their inhibition by a sweet response inhibitor, gurmarin. The results showed that responses to sucrose, saccharin, glycine, L-alanine, and D-tryptophan, but not to D-phenylalanine, were approximately 1.5 times greater in db/db mice than in control mice. Treatment of the tongue with gurmarin suppressed responses to these sweeteners in db/db and control mice, but the extent of suppression was considerably smaller in db/db mice. The magnitudes of gurmarin-sensitive components of the response to sweeteners in db/db mice were not significantly different from those in control mice, whereas the magnitudes of gurmarin-insensitive components in db/db mice were about twice as large as those in control mice. These results suggest that the enhancement of chorda tympani responses in db/db mice to sucrose and other nonsugar sweeteners may occur through gurmarin-insensitive membrane components.

References

Nov 20, 1992·Brain Research·Y NinomiyaH Katsukawa
May 1, 1991·Physiology & Behavior·Y NinomiyaM Funakoshi
Jan 1, 1989·Archives of Histology and Cytology·A NikiT Hashioka
Nov 1, 1989·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·Y NinomiyaM Funakoshi
Nov 1, 1974·Diabetologia·D L Coleman, K P Hummel
Jan 1, 1981·The Japanese Journal of Physiology·Y Ninomiya, M Funakoshi
Feb 15, 1996·Nature·G H LeeJ M Friedman
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·J S Flier
Mar 17, 1997·Biochemical and Biophysical Research Communications·N HoggardL M Williams

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