PMID: 7335552Jan 1, 1981Paper

Enhanced responses to muscarine in rats treated chronically with atropine

Polish Journal of Pharmacology and Pharmacy
Z S Herman, J Słominska-Zurek

Abstract

Rats were treated for 14 or 30 days with 10 mg/kg sc atropine (AT) daily. 24 h after the last dose of At, 50 micrograms of muscarine (MU) was injected intracerebroventricularly (ivtr.). Long-term atropinization enhanced the behavior induced by MU. These data support our previous suggestion that chronic blockade of central muscarinic receptors induces their hypersensitivity.

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