PMID: 2114322Jul 2, 1990Paper

Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells

FEBS Letters
T YamauchiH Nawata

Abstract

We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-1-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release. These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium, which might be involved in the developments of vascular complications and atherosclerosis.

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Citations

Dec 13, 2000·Diabetes/metabolism Research and Reviews·S ChakrabartiS Chen
Aug 31, 2002·Diabetes/metabolism Research and Reviews·Riccardo Candido, Terri J Allen
Sep 12, 2000·Current Hypertension Reports·D B Corry, M L Tuck
Jan 1, 1994·Life Sciences·E MorabitoE A Martelli
Sep 1, 1995·Neuroscience Letters·L Bômont, E T MacKenzie
Mar 18, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Dalia SomjenNaftali Stern
May 2, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Pervin VuralMukaddes Canbaz
Sep 18, 1998·Diabetes Research and Clinical Practice·H Haller
Aug 26, 1999·Diabetes Research and Clinical Practice·W G MayhanG M Sharpe
May 10, 2001·Journal of the American College of Cardiology·L E SpiekerT F Lüscher
May 5, 2000·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·V Dilsizian
Feb 28, 2001·Diabetes, Obesity & Metabolism·K Jandeleit-DahmM E Cooper
Sep 30, 2000·Kidney International·G M HargroveN C Wong
Nov 25, 2003·Kidney International·Stanislao MorgeraHans-Hellmut Neumayer
Apr 1, 1992·Clinical and Experimental Pharmacology & Physiology·P J TammesildR G King
Apr 8, 2011·The Journal of Pharmacology and Experimental Therapeutics·Mohamed A SalehDavid M Pollock
Jun 1, 1995·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·J K Shoemaker, A Bonen
Nov 11, 2005·Critical Care : the Official Journal of the Critical Care Forum·Vladimir KuklinLars Bjertnaes
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·L E SpiekerT F Lüscher
Mar 5, 2013·Heart Failure Reviews·Adriana Adameova, Naranjan S Dhalla
Nov 19, 2013·Investigative Ophthalmology & Visual Science·Luke B PottsTravis W Hein
Apr 13, 2007·Digestive Diseases and Sciences·Bulent DegertekinGulen Akyol
Aug 5, 2015·Journal of Clinical Medicine·Lidia AnguianoMaría José Soler
Feb 1, 1996·Kidney International·J Egido
May 9, 2014·Kidney International·Donald E Kohan, Matthias Barton

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