PMID: 11925358Apr 2, 2002Paper

Enhanced semantic priming in schizophrenia: a computer model based on excessive pruning of local connections in association cortex

The British Journal of Psychiatry : the Journal of Mental Science
Peter J Siekmeier, Ralph E Hoffman

Abstract

Many studies have found that people with schizophrenia exhibit abnormally high levels of semantic priming. Post-mortem and neuroimaging studies of schizophrenia suggest a reduction of neuritic processes (dendrites and synapses). To demonstrate that reductions in neuritic processes can produce excessive priming in patients with schizophrenia. Associative memory was simulated using a computer-based neural network system consisting of two interactive neural groups, one coding for individual memories and the other for the category to which each memory belonged. Variation of a single parameter determining the density of local connections within the two neuronal groups gave a close approximation to levels of memory access and semantic priming previously reported in normal subjects and in patients with schizophrenia. This study suggests that schizophrenia arises from excessive pruning of local connections in association cortex. Its findings shed light on the mechanisms underlying cognitive priming more generally, and how it might emerge developmentally.

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Citations

Jan 29, 2010·Journal of Autism and Developmental Disorders·Suzanna N Russell-SmithDonna M Bayliss
Jun 27, 2008·The Behavioral and Brain Sciences·Bernard Crespi, Christopher Badcock
Aug 5, 2009·PloS One·Lucia M Talamini, Martijn Meeter
Mar 15, 2011·Biological Psychiatry·Ralph E HoffmanRisto Miikkulainen
Jan 16, 2008·Applied & Preventive Psychology : Journal of the American Association of Applied and Preventive Psychology·Randall K Minas, Sohee Park
Nov 3, 2006·Consciousness and Cognition·Yossi Guterman
Apr 8, 2006·Trends in Pharmacological Sciences·Ildiko Aradi, Péter Erdi
Dec 17, 2014·Frontiers in Human Neuroscience·Evelina Leivada, Cedric Boeckx
Jan 9, 2015·Neural Networks : the Official Journal of the International Neural Network Society·Mauro UrsinoElisa Magosso
May 12, 2015·Clinical Psychological Science : a Journal of the Association for Psychological Science·Alan AnticevicDeanna M Barch
Jun 27, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hans Liljenström
Sep 14, 2021·Frontiers in Cellular Neuroscience·Lea FritschiKerstin Lenk

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