PMID: 9450678Feb 5, 1998Paper

Enhanced serum response element binding activity correlates with down-regulation of c-fos mRNA expression in the rat brain following repeated cortical lesions

Brain Research. Molecular Brain Research
S IvkovicS Ruzdijic

Abstract

Repeated lesions of rat cerebral cortex result in transient peaks in the level of the c-fos transcript, but after the second lesion, this peak is substantially diminished. Using this lesion paradigm, we have analyzed the participation of the c-fos promoter elements SRE and DSE in the regulation of c-fos transcription. Following a single lesion, SRE/DSE binding activity peaked at 2 h, subsequent to the maximal levels of c-fos mRNA and parallel to the peak of c-Fos protein. After a second lesion (reinduction), 4 h following the initial lesion, SRE/DSE binding activity peaked after only 30 min and was significantly higher than following the first lesion. Once again, this peak occurred after the peak of c-fos mRNA expression and parallel with the second peak of c-Fos protein expression. These results suggested that the SRE and DSE promoter elements participated in the induction and down-regulation of c-fos transcription in vivo and suggested the possible involvement of Fos protein in its own regulation. The ability of Fos/Fra proteins to participate in a transcriptional complex was confirmed in gel-shift experiments with an AP-1 element, and the biphasic trend of binding activity was observed. Supershift experiments were performed ...Continue Reading

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Citations

Jan 3, 2003·Neurochemistry International·Desanka MilanovićSabera Ruzdijić
Mar 29, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Natasa TerzicSabera Ruzdijic
Jun 22, 2019·Korean journal of anesthesiology·Seongheon Lee

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