Enhanced SMARCD1, a subunit of the SWI/SNF complex, promotes liver cancer growth through the mTOR pathway

Clinical Science
Yongjie ZhouHong Bu

Abstract

The chromatin remodeling complex SWI/SNF regulates the accessibility of target genes to transcription factors and plays a critical role in the tumorigenesis of hepatocellular carcinoma (HCC). The SWI/SNF complex is assembled from approximately fifteen subunits, and most of these subunits have distinct roles and are often aberrantly expressed in HCC. A comprehensive exploration of the expression and clinical significance of these subunits would be of great value. In the present study, we obtained the gene expression profile of each SWI/SNF subunit and the corresponding clinical information from The Cancer Genome Atlas (TCGA). We found that fourteen out of the fifteen SWI/SNF subunits were significantly increased in HCC tissues compared to paired normal liver tissues, and eleven subunits were significantly associated with overall survival (OS). We identified a four-gene prognostic signature including ACTL6A, ARID1A, SMARCC1 and SMARCD1 that could effectively predict OS in HCC patients. Among the genes, SMARCD1 has the most prognostic value. We further conducted in vitro and in vivo experiments and revealed that SMARCD1 promotes liver cancer growth by activating the mTOR signaling pathway. In conclusion, our study has revealed tha...Continue Reading

References

Apr 21, 2001·Molecular and Cellular Biology·C J GuidiS N Jones
Feb 22, 2005·Applied Immunohistochemistry & Molecular Morphology : AIMM·David N ReismanWilliam K Funkhouser
May 19, 2006·Cancer Research·Marjorie Coisy-QuivyJean-Christophe Dantonel
Jul 20, 2007·Oncogene·S J BultmanT Magnuson
Feb 28, 2008·Nuclear Receptor Signaling·Kevin W Trotter, Trevor K Archer
May 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xiaolin GaoZhong Wang
Jun 3, 2009·Genes & Development·David GatfieldUeli Schibler
Apr 30, 2010·Bioinformatics·Matthew D Wilkerson, D Neil Hayes
Jul 16, 2010·Trends in Cell Biology·Gary Davidson, Christof Niehrs
Jul 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Weiwei TaoChang Liu
Oct 24, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Mio EndoToshikazu Yoshikawa
Sep 10, 2014·Cancer Cell·Katherine C HelmingCharles W M Roberts
Dec 25, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shuai XiaoLian-Yue Yang
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Apr 30, 2016·Nutrition & Metabolism·Ping ZhangFeiruo Huang
Jun 18, 2017·Cell·UNKNOWN Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu, UNKNOWN Cancer Genome Atlas Research Network
Feb 3, 2018·Scientific Reports·Jose A Guerrero-Martínez, Jose C Reyes
Nov 8, 2018·Nature·Lei ChangStefano Piccolo
Feb 13, 2019·International Journal of Biological Sciences·Furao LiuDong Li
Jan 25, 2020·Annual Review of Pathology·Yemin WangDavid G Huntsman
Feb 6, 2020·Cell Death & Disease·Pan WangXin Chen

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Citations

Apr 28, 2021·Journal of Experimental & Clinical Cancer Research : CR·Yan LiChuanyong Guo
Jun 15, 2021·Canadian Journal of Gastroenterology & Hepatology·Mengnan GuoJinghua Wu

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